Patents by Inventor Jacek Ostrowski

Jacek Ostrowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic combinations of RAR antagonists and RXR agonists and use thereof
    Patent number: 6130230
    Abstract: The present invention provides compositions and methods for treating an animal, preferably a human, suffering from or predisposed to a physical disorder by administering an effective amount of a composition comprising at least one RAR antagonist, preferably an RAR.alpha. antagonist, and at least one RXR agonist. The combination of an RXR agonist, which has no therapeutic effects alone, with an RAR antagonist allows the use of lower doses of the RAR antagonist than were previously thought to be efficacious; this approach obviates many of the undesirable physiological side-effects of treatment with RAR antagonists.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: October 10, 2000
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifiques, Universite Louis Pasteur, Bristols-Myers Squibb Company
    Inventors: Pierre Chambon, Hinrich Gronemeyer, Peter R. Reczek, Jacek Ostrowski
  • Retinoid-like compounds
    Patent number: 6008251
    Abstract: The present invention relates to a compound of the formula ##STR1## wherein X is --CONH-- or --NHCO--, or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.The compounds of the present invention exhibit retinoid-like properties and are thus useful as antiinflammatory agents for chronic skin inflammatory diseases such as psoriasis and atopic dermatitis, as agents for the treatment of rheumatic diseases such as rheumatoid arthritis, as antitumor agents for the treatment of various tumors, and as agents for the treatment of non-malignant proliferative skin conditions.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: December 28, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Fred C. Zusi, Peter R. Reczek, Jacek Ostrowski