Abstract: The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors having the structure shown below: wherein R and R1 are as defined herein. The 2-arylamino-4 -(aminoalkylene)aminopyrimidines inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4 -(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-?). The PKC-? inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Abstract: After an initial separation of paper, plastics and the light fibrous types of materials, as well as magnetically removable ferrous metals, from refuse material, the remaining mixed solid materials are projected outwardly in a generally horizontal path and subjected to a "flight-path" type of segregation where a magnetic field is used to influence and lessen the length of the trajectory of the conductive metals in the mixture of materials. The magnetic field induces a retarding force related to the size, conductivity and to some extent to the shape of the fragments which, in combination with the force of gravity, modifies the trajectory of different materials. As a result, fragments of different types of materials will tend to "drop out" at different distances along the general flight path according to their individual electrical conductivity properties.

Abstract: After an initial separation of paper, plastics and the light fibrous types of materials, as well as magnetically removable ferrous metals, from refuse material, it is subjected to a "time-of-flight" type of segregation where a magnetic field is used to influence the downward free-fall of the remaining mixed solids materials. In combining a magnetic field with gravity fall, there is a retarding force on each conductive piece of material which is related to its conductivity and volume. As a result, different types of material fragments of about the same size will have different descent times in the drop zone which will depend primarily upon density and electrical conductivity and a rotatable diverter means, which is properly timed and synchronized in its movement with respect to the releases of unsegregated material, can provide for the deflection of the different types of materials into appropriate collecting zones.

Abstract: A method of forming membrane covered laminate strips of a desired predetermined length from an elongated porous strip wherein said strip is impregnated at spaced predetermined sections with a fluid seal material to preclude fluid flow through such sections and is also coated on each face with a suitable membrane forming coating material to thereby form a laminate strip suitable for reverse osmosis and/or ultrafiltration usage. The resulting laminate strip is provided with a punched hole in a portion of the impregnated section to effect a fluid passageway opening therethrough and, additionally, is cut transversely through an intermediate portion of such section to result in the formation of a multiplicity of predetermined length laminate strips. A plurality of stacked strips, with the punched hole positions staggered in adjacent strips, or groups of strips, provides a simplified form of apparatus with an elongated serpentine flow path therethrough for separating the constituents of a fluid feed stream.