Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: A pill container and cap for storing and dispensing medication is described. In various embodiments, the pill container comprises an outer shell having an angled corner section, a constriction within the outer shell configured to limit flow of the medication out of the container a cap to seal the container. Various additional features and component are also described.

Abstract: A pill container and cap for storing and dispensing medication is described. In various embodiments, the pill container comprises an outer shell having an angled corner section, a constriction within the outer shell configured to limit flow of the medication out of the container a cap to seal the container. Various additional features and component are also described.

Abstract: A tamper-evident closure assembly for a container having an opening includes a cap configured to be secured with the container to cover the opening. A tamper-evidencing member is carried by the cap and is configured to provide an indication when the cap is removed from the container. The closure assembly further includes an outer shell having a central aperture through which the cap is received. The outer shell and the cap may be configured to cooperate with each other such that the cap is operatively secured to, and mounted so as to be non-rotatable relative to, the outer shell. Systems for storing material and methods of closing a container and assembling a closure assembly are also provided.

Abstract: A pill container and cap for storing and dispensing medication is described. In various embodiments, the pill container comprises an outer shell having an angled corner section, a constriction within the outer shell configured to limit flow of the medication out of the container a cap to seal the container. Various additional features and component are also described.

Abstract: A portable, hand-held device for dispensing both fluid hand sanitizer and dry wipes is described. In various embodiments, the portable hand sanitizer device has a lower assembly comprising a means for storing and dispensing dry wipes and a means for blocking actuation and dispensing of a fluid sanitizer, and the upper assembly comprises a means for dispensing fluid sanitizer and a means for engaging or not engaging the actuation block.

Abstract: A portable, hand-held device for dispensing both fluid hand sanitizer and dry wipes is described. In various embodiments, the portable hand sanitizer device has a lower assembly comprising a means for storing and dispensing dry wipes and a means for blocking actuation and dispensing of a fluid sanitizer, and the upper assembly comprises a means for dispensing fluid sanitizer and a means for engaging or not engaging the actuation block.

Abstract: A tamper-evident closure assembly is provided for a container having a neck defining an opening. The closure assembly includes a base cap configured for securing with the neck of the container. The base cap includes an aperture for providing access to the opening of the container in the neck. The closure assembly further includes an overcap configured for securing with the base cap and configured to cover the aperture in the base cap when the overcap is secured to the base cap. First and second tamper-evidencing members are associated with the base cap and the overcap, respectively. The first tamper-evidencing member provides an indication when the base cap has been removed from the neck, and the second tamper-evidencing member provides an indication when the overcap has been removed from the base cap.

Abstract: A tamper-evident closure assembly for a container having an opening includes a cap configured to be secured with the container to cover the opening. A tamper-evidencing member is carried by the cap and is configured to provide an indication when the cap is removed from the container. The closure assembly further includes an outer shell having a central aperture through which the cap is received. The outer shell and the cap may be configured to cooperate with each other such that the cap is operatively secured to, and mounted so as to be non-rotatable relative to, the outer shell. Systems for storing material and methods of closing a container and assembling a closure assembly are also provided.

Abstract: A tamper-evident closure assembly for a container includes a cap configured to be secured with the container to cover the opening. A tamper-evidencing member is carried by the cap and is configured to provide an indication when the cap is removed from the container. The closure assembly further includes an outer shell having a central aperture through which the cap is received. The outer shell and the cap may be configured to cooperate with each other such that the cap is operatively secured to, and mounted so as to be non-rotatable relative to, the outer shell. A system for storing material and a method of closing a container are also provided.

Abstract: A fingerloop tote handle for a container includes a tote ring and a handle connected via a tether member for assisting a user in carrying the container. The container includes a first rib projecting outwardly therefrom. The tote ring engages the first rib of the container, and the handle has a top surface and an aperture extending therethrough, with the aperture being defined as a pair of opposing and connecting major arcs configured for receiving a pair of adjacent fingers of the user. The top surface has a beveled edge adjacent to and surrounding the aperture. The tether member extends between and connects the tote ring and the handle such that the tether member radially outwardly supports the handle relative to the container.

Abstract: A product container includes a top portion defining an opening, a bottom portion defining a base, and a central portion including a plurality of sidewalls extending between the top and bottom portions. Three of the sidewalls include discrete planar facets that collectively define a narrowed waist portion, at which the product container has smaller dimensions or a smaller cross sectional area compared to the top portion and the bottom portion. The narrowed waist portion is configured to be gripped by a user for lifting the product container (even when wearing gloves), and a flat product label may also be placed on the product container at the narrowed waist portion. The narrowed waist portion provides a natural gripping location as well as clearance between abutting product containers when multiple abutting product containers are located on a shelf.

Abstract: A tamper-evident closure assembly for a container includes a cap configured to be secured with the container to cover the opening. A tamper-evidencing member is carried by the cap and is configured to provide an indication when the cap is removed from the container. The closure assembly further includes an outer shell having a central aperture through which the cap is received. The outer shell and the cap may be configured to cooperate with each other such that the cap is operatively secured to, and mounted so as to be non-rotatable relative to, the outer shell. A system for storing material and a method of closing a container are also provided.

Abstract: A fingerloop tote handle for a container includes a tote ring and a handle connected via a tether member for assisting a user in carrying the container. The container includes a first rib projecting outwardly therefrom. The tote ring engages the first rib of the container, and the handle has a top surface and an aperture extending therethrough, with the aperture being defined as a pair of opposing and connecting major arcs configured for receiving a pair of adjacent fingers of the user. The top surface has a beveled edge adjacent to and surrounding the aperture. The tether member extends between and connects the tote ring and the handle such that the tether member radially outwardly supports the handle relative to the container.

Abstract: A product container includes a top portion defining an opening, a bottom portion defining a base, and a central portion including a plurality of sidewalls extending between the top and bottom portions. Three of the sidewalls include discrete planar facets that collectively define a narrowed waist portion, at which the product container has smaller dimensions or a smaller cross sectional area compared to the top portion and the bottom portion. The narrowed waist portion is configured to be gripped by a user for lifting the product container (even when wearing gloves), and a flat product label may also be placed on the product container at the narrowed waist portion. The narrowed waist portion provides a natural gripping location as well as clearance between abutting product containers when multiple abutting product containers are located on a shelf.

Abstract: A tamper-evident closure assembly is provided for a container having a neck defining an opening. The closure assembly includes a base cap configured for securing with the neck of the container. The base cap includes an aperture for providing access to the opening of the container in the neck. The closure assembly further includes an overcap configured for securing with the base cap and configured to cover the aperture in the base cap when the overcap is secured to the base cap. First and second tamper-evidencing members are associated with the base cap and the overcap, respectively. The first tamper-evidencing member provides an indication when the base cap has been removed from the neck, and the second tamper-evidencing member provides an indication when the overcap has been removed from the base cap.

Abstract: The embodiments described herein illustrate a cap for a container comprising a cap body that includes an upper portion and a lower portion. The lower portion has an outer circumferential sidewall defining a ring-positioning member. The cap also has a ring that includes an outer member selectively engaging the ring-positioning member and an inner member disposed proximate an inside surface of the lower portion. The inner member has at least one tab extending inwardly and upwardly and terminating at a first edge. The inner member also has at least one finger member protruding inwardly from the inner member and terminating at a second edge above the first edge of the tab.

Abstract: The embodiments described herein illustrate a cap for a container comprising a cap body that includes an upper portion and a lower portion. The lower portion has an outer circumferential sidewall defining a ring-positioning member. The cap also has a ring that includes an outer member selectively engaging the ring-positioning member and an inner member disposed proximate an inside surface of the lower portion. The inner member has at least one tab extending inwardly and upwardly and terminating at a first edge. The inner member also has at least one finger member protruding inwardly from the inner member and terminating at a second edge above the first edge of the tab.