Patents by Inventor Jack Benner

Jack Benner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Overexpression, purification and characterization of a thermolabile phosphatase
    Patent number: 7319014
    Abstract: Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided. Uses for TAP include dephosphorylation of nucleic acids, sugars, peptides and proteins. TAP as described herein has advantages over phosphatases from other sources with respect to thermolability at 65° C. and efficiency of dephosphorylation activity at approximately neutral pH.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: January 15, 2008
    Assignee: New England Biolabs, Inc.
    Inventors: Ellen Guthrie, Theodore Davis, Jack Benner, II
  • Novel modular type II restriction endonuclease, cspci, and the use of modular endonucleases for generating endonucleases with new specificities
    Publication number: 20070166719
    Abstract: A novel restriction endonuclease and methods of making the same are obtainable from either Citrobacter species 2144 (NEB#1398) or the recombinant stain Escherichia coli (NEB#1554) which cleaves at nt sequence 5?-CAANNNNNGTGG-3? (SEQ ID NO:14) in double-stranded DNA molecules. The novel restriction endonuclease is a modular protein in which the specificity moiety is an independent module from the restriction-modification module.
    Type: Application
    Filed: March 23, 2005
    Publication date: July 19, 2007
    Applicant: New England Biolabs, Inc.
    Inventors: Richard Morgan, Geoffrey Wilson, Keith Lunnen, Daniel Heiter, Jack Benner, Celine Nkenfou, Stephen Picone
  • Overexpression, purification and characterization of a thermoolabile phosphatase
    Publication number: 20060252118
    Abstract: Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided. Uses for TAP include dephosphorylation of nucleic acids, sugars, peptides and proteins. TAP as described herein has advantages over phosphatases from other sources with respect to thermolability at 65° C. and efficiency of dephosphorylation activity at approximately neutral pH.
    Type: Application
    Filed: February 20, 2004
    Publication date: November 9, 2006
    Inventors: Ellen Guthrie, Theodore Davis, Jack Benner
  • Method for cloning and expression of Tth111II restriction endonuclease-methylase in E. coli
    Patent number: 6919194
    Abstract: The present invention relates to recombinant DNA which encodes the Tth111II restriction endonuclease-methylase fusion protein (Tth111IIRM), expression of Tth111II restriction endonuclease-methylase fusion protein in E. coli cells containing the recombinant DNA, and purification of Tth111II endonuclease-methylase fusion protein to near homogeneity.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: July 19, 2005
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Derek Robinson, Jack Benner, Shuang-yong Xu
  • Method for cloning and expression of TTH111II restriction endonuclease-methylase in E. coli
    Publication number: 20040132129
    Abstract: The present invention relates to recombinant DNA which encodes the Tth111II restriction endonuclease-methylase fusion protein (Tth111IIRM), expression of Tth111II restriction endonuclease-methylase fusion protein in E. coli cells containing the recombinant DNA, and purification of Tth111II endonuclease-methylase fusion protein to near homogeneity.
    Type: Application
    Filed: January 8, 2003
    Publication date: July 8, 2004
    Applicant: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Derek Robinson, Jack Benner, Shuang-Yong Xu
  • Method for cloning and expression of BseRI restriction endonuclease and BseRI methylase in E. coli
    Patent number: 6593122
    Abstract: The present invention relates to recombinant DNA that encodes the BseRI restriction endonuclease as well as M.BseRI, expression of BseRI restriction endonuclease and M.BseRI in E. coli cells containing the recombinant DNA.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: July 15, 2003
    Assignee: New England Biolabs, Inc.
    Inventors: Shuang-yong Xu, Robert Maunus, Jack Benner
  • Method for cloning and expression of TspRI restriction endonuclease and TspRI methylase in E. coli
    Patent number: 6589769
    Abstract: The present invention relates to recombinant DNA that encodes the TspRI restriction endonuclease as well as TspRI methylase, expression of TspRI restriction endonuclease and TspRI methylase in E. coli cells containing the recombinant DNA.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: July 8, 2003
    Assignee: New England Biolabs, Inc.
    Inventors: Shuang-yong Xu, Andrew Dore, Michael Dalton, Jack Benner