Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes opposing first and second ends. Multiple portions form the first end of the body and part of a remainder of the body between the first and second ends. The first and second ends are wider than the remainder of the body. The multiple portions of the body are separated by empty space such that the multiple portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end of the body. The second end of the body is integral with the remainder of the body and not divided into multiple separated portions.

Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the first and second ends. The first portions of the body are separated by empty space, and the first and second ends are wider than the remainder of the body. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. At least part of the insert, prior to insertion between the first portions of the body, has a shape complementary to a shape of the empty space.

Abstract: A system includes a scleral prosthesis and an insert. The scleral prosthesis includes an elongated body having a first free end and a second free end opposite the first end. A maximum width of the body at each end is wider than a maximum width of the body between the ends. The body includes multiple first portions that form the first end of the body and a part of the body between the ends. The first portions are separated lengthwise along a substantial portion of a total length of the body. The first portions are biased so that they maintain separation from one another without external interference but are configured to be pushed towards each other. The insert is configured to be placed between the first portions to maintain a separation of the first portions. The body and/or the insert could be formed using one or more magnetic materials.

Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the ends. The first and second ends are wider than the remainder of the body. The first portions of the body are separated lengthwise along the body by empty space such that the first portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. The insert has a length that is at least about half of a length of the elongated body.

Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes opposing first and second ends. Multiple portions form the first end of the body and part of a remainder of the body between the first and second ends. The first and second ends are wider than the remainder of the body. The multiple portions of the body are separated by empty space such that the multiple portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end of the body. The second end of the body is integral with the remainder of the body and not divided into multiple separated portions.

Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the ends. The first and second ends are wider than the remainder of the body. The first portions of the body are separated lengthwise along the body by empty space such that the first portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. The insert has a length that is at least about half of a length of the elongated body.

Abstract: A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the first and second ends. The first portions of the body are separated by empty space, and the first and second ends are wider than the remainder of the body. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. At least part of the insert, prior to insertion between the first portions of the body, has a shape complementary to a shape of the empty space.

Abstract: A system includes a scleral prosthesis and an insert. The scleral prosthesis includes an elongated body having a first free end and a second free end opposite the first end. A maximum width of the body at each end is wider than a maximum width of the body between the ends. The body includes multiple first portions that form the first end of the body and a part of the body between the ends. The first portions are separated lengthwise along a substantial portion of a total length of the body. The first portions are biased so that they maintain separation from one another without external interference but are configured to be pushed towards each other. The insert is configured to be placed between the first portions to maintain a separation of the first portions. The body and/or the insert could be formed using one or more magnetic materials.

Abstract: A system includes a scleral prosthesis and an insert. The scleral prosthesis includes an elongated body having a first free end and a second free end opposite the first end. A maximum width of the body at each end is wider than a maximum width of the body between the ends. The body includes multiple first portions that form the first end of the body and a part of the body between the ends. The first portions are separated lengthwise along a substantial portion of a total length of the body. The first portions are biased so that they maintain separation from one another without external interference but are configured to be pushed towards each other. The insert is configured to be placed between the first portions to maintain a separation of the first portions. The body and/or the insert could be formed using one or more magnetic materials.

Abstract: Various ocular fixation devices are disclosed. One ocular fixation device includes first and second rings, where at least one of the rings includes means for fixating ocular tissue of an eye. The means for fixating are arranged to grasp the ocular tissue of the eye and to release the ocular tissue of the eye based on rotation of at least one of the first and second rings. The ocular fixation device may also include one or more structures on which a surgical tool can be mounted on the ocular fixation device at one or more locations. For instance, a dome of the ocular fixation device could include one or more holes that are configured to receive one or more projections from the surgical tool. As another example, a base of the ocular fixation device could include one or more notches configured to receive a projection from the surgical tool.

Abstract: A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.

Abstract: A surgical tool includes a surgical blade configured to be moved to form an incision. The surgical tool also includes a wire configured to cause movement of the surgical blade. The surgical tool further includes an actuator configured to shorten a length of the wire to cause the movement of the surgical blade. The surgical tool could be configured to move the surgical blade in a first direction and then in a second direction in response to a single shortening of the wire. Also, the wire could represent a first wire, the surgical tool could include a second wire, and the surgical tool could be configured to move the surgical blade in a first direction in response to shortening the first wire and to move the surgical blade in a second direction in response to shortening the second wire.

Abstract: One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

Abstract: One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

Abstract: An ocular fixation device includes a body configured to be placed on an eye. The ocular fixation device also includes multiple twist picks configured to be turned to secure the body to the eye and to release the body from the eye. The body includes connection points on which a surgical tool is mountable on the body.

Abstract: A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.