Patents by Inventor Jack Chirikjian

Jack Chirikjian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Real-time detection of amplicons using nucleic acid repair enzymes
    Publication number: 20060115838
    Abstract: Target nucleic acid sequences can be detected during an amplification reaction in real-time. Detection methods involve conducting an amplification reaction in the presence of at least one nucleic acid repair enzyme and at least one oligonucleotide probe that contains a mismatched or repairable base sequence such that a mismatch occurs at the site of the mismatched or repairable base sequence. Reaction mixtures and kits for detecting target nucleic acids also are provided.
    Type: Application
    Filed: October 19, 2005
    Publication date: June 1, 2006
    Inventors: Leonard Bazar, Jack Chirikjian
  • Fluorometric assay for detecting nucleic acid cleavage
    Patent number: 6787304
    Abstract: A method of detecting an enzyme-mediated DNA cleavage reaction in a fluorometric assay is provided. The method can be used to detect DNA cleavage caused by restriction endonucleases, retroviral integrase enzymes, DNases, RNases, or enzymes utilized in other strand separating processes in molecular biology.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: September 7, 2004
    Assignee: Georgetown University
    Inventors: Myun Ki Han, S. Paul Lee, Jack Chirikjian