Abstract: A method of natural language processing (NLP) of an input provided by a user describing a symptom being experienced by the user relating to a vehicle issue, and the automatic identification of a feature of the vehicle associated with the identified vehicle issue that may represent a risk of damage to the vehicle when operated in the presence of the vehicle issue. The method includes obtaining an input sequence comprising a sequence of words describing the symptom associated with the vehicle issue, processing the input sequence using a NLP engine to classify the input sequence as a predicted vehicle issue and based on the predicted issue, identifying the feature of the vehicle whereby continued use of the feature is associated with a risk of damage to the vehicle due to the predicted issue. An indication can be transmitted to the vehicle to remotely disable the identified feature.

Abstract: Embodiments of the disclosed technology are directed to a method of natural language processing (NLP) of an input provided by a user describing a symptom being experienced by the user relating to a vehicle issue, and the automatic identification of a software update operable to mitigate the vehicle issue. The method includes obtaining an input sequence comprising a sequence of words describing the symptom associated with the vehicle issue, processing the input sequence using a NLP engine to classify the input sequence as a predicted vehicle issue and based on the predicted issue, identifying a software update operable to mitigate the identified issue. The identified software update can then be transmitted to the vehicle for install, thus automatically and remotely affecting repair of mitigation for the vehicle issue.

Abstract: A system suitable for delivering a therapeutic agent to a target site may include a container for holding a therapeutic agent, a pressure source having pressurized fluid, where the pressure source is in selective fluid communication with at least a portion of the container, a catheter in selective fluid communication with the container and configured for delivery of the therapeutic agent to a target site, a first valve connected between the container and the catheter, a second valve connected between the pressure source and the container, a button configured to selectively actuate the second valve, and a brake assembly coupled to the first valve and configured to selectively permit actuation of the second valve, such that when the first valve is in a first state, the brake assembly blocks the button such that the button does not actuate the second valve.

Abstract: A system suitable for delivering a therapeutic agent to a target site may include a container for holding a therapeutic agent; a pressure source having pressurized fluid, the pressure source in selective fluid communication with at least a portion of the container; a catheter in selective fluid communication with the container and configured for delivery of the therapeutic agent or the pressurized fluid to a target site; and a housing configured to securely retain the container and movably support a switch, where the switch is movable between a first position and a second position, where when the switch is in the first position, delivery of the therapeutic agent is prevented while delivery of the pressurized fluid is permitted, and where when the switch is in the second position, delivery of the therapeutic agent is permitted.

Abstract: A system suitable for delivering a therapeutic agent to a target site may include a container for holding a therapeutic agent, a pressure source having pressurized fluid, where the pressure source is in selective fluid communication with at least a portion of the container, a catheter in selective fluid communication with the container and configured for delivery of the therapeutic agent to a target site, a first valve connected between the container and the catheter, a second valve connected between the pressure source and the container, a button configured to selectively actuate the second valve, and a brake assembly coupled to the first valve and configured to selectively permit actuation of the second valve, such that when the first valve is in a first state, the brake assembly blocks the button such that the button does not actuate the second valve.

Abstract: A system for delivering an agent including a plurality of particles to a target site. The system incudes a catheter having a first wall defining an inner lumen for delivery of the agent to the target site, and a second wall surrounding the first wall to define an outer lumen therebetween for delivery of a fluid to the target site. The catheter has a distal end terminating with a primary opening of the inner lumen and a secondary opening of the outer lumen. A hub associated with a proximal end of the catheter includes a first inlet for receiving a supply of the agent and a second inlet for receiving a supply of the fluid, wherein the first inlet is in fluid communication with the inner lumen, and the second inlet is in fluid communication with the outer lumen.

Abstract: A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.

Abstract: An ultrasonic diagnostic imaging system is provided in which the scanhead connectors are elevated and tilted upward. This is provided by a tilted card cage with a backplane mount for the scanhead connectors which extends above the top of the card cage. The elevated and tilted scanhead connectors provide a comfortable position and orientation for the system operator when inserting and removing probe connectors, and the elevated position keeps the probe cables well above the floor and entanglement with the wheels.

Abstract: An ultrasonic diagnostic imaging system is provided in which the scanhead connectors are elevated and tilted upward. This is provided by a tilted card cage with a backplane mount for the scanhead connectors which extends above the top of the card cage. The elevated and tilted scanhead connectors provide a comfortable position and orientation for the system operator when inserting and removing probe connectors, and the elevated position keeps the probe cables well above the floor and entanglement with the wheels.

Abstract: The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria.

Abstract: A portable steam bath having a rigid, bracket-supported top including a heat lamp, and a curtain depending therefrom to a rigid tub of the same size and general configuration as the top, the tub being connectible with a steam generator, water supply and safety electric units, all of which, together with the curtain, may be placed in the top and tub, which combination unit may then be connected and carried as a suitcase.

Abstract: A pair of telescoped inner and outer tubes together provide a post-like handle that is mounted on the gunwale of a boat. The outer tube is fixed to the top of the gunwale and projects down through a hole in the gunwale, and the inner tube which forms the actual handle slides in the outer tube between a lowered inoperative position beneath the gunwale to a raised operative position standing erect and rising to a convenient height above the gunwale. A spring-pressed latch moves with the inner tube and snaps into an annular groove that is fixed with respect to the outer tube and located directly above the gunwale, to secure the inner tube against either upward or downward movement. A resiliently manually actuated loop located in the annular groove enables the latch to be dislodged from the groove when it is desired to lower the handle.