Patents by Inventor Jack Dale Leber

Jack Dale Leber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF AKT ACTIVITY
    Publication number: 20100056523
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: November 9, 2006
    Publication date: March 4, 2010
    Inventors: Dirk A. Heerding, Tammy J. Clark, Jack Dale Leber, Igor Safonov
  • Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors
    Patent number: 7625890
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: December 1, 2009
    Assignee: SmithKline Beecham Corp.
    Inventors: Dirk A. Heerding, Tammy J. Clark, Jack Dale Leber, Igor Safonov
  • INHIBITORS OF AKT ACTIVITY
    Publication number: 20090227616
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: November 9, 2006
    Publication date: September 10, 2009
    Inventors: Dirk A. Heerding, Tammy J. Clark, Jack Dale Leber, Igor Safonov, Mie Li
  • Inhibitors of Akt Activity
    Publication number: 20080269131
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: November 9, 2006
    Publication date: October 30, 2008
    Inventors: Dirk A. Heerding, Tammy J. Clark, Jack Dale Leber, Igor Safonov
  • Inhibitors of Akt Activity
    Publication number: 20080255143
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: July 28, 2004
    Publication date: October 16, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Dirk A. Heerding, Tammy J. Clark, David Harold Drewry, Jack Dale Leber, Igor Safonov, Dennis S. Yamashita
  • Peptide deformylase inhibitors
    Patent number: 7166624
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: January 23, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jack Dale Leber, Mei Li, Jinhwa Lee, Kelly M. Aubart, Siegfried B. Christensen, IV
  • Fatty acid synthase inhibitors
    Publication number: 20030220392
    Abstract: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
    Type: Application
    Filed: November 25, 2002
    Publication date: November 27, 2003
    Inventors: Jack Dale Leber, Siegfried Benjamin Christensen, Robert A Daines, Mei Li, Joseph Weinstock, Martha S Head
  • Endothelin receptor antagonists
    Patent number: 6448260
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Publication number: 20020002177
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Application
    Filed: July 10, 2001
    Publication date: January 3, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Patent number: 6274737
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: August 14, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Patent number: 6271399
    Abstract: Indane and indene compounds are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 7, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Apparatus and process for arraying beads
    Patent number: 6255116
    Abstract: A mixture of beads from a combinatorial library is held in suspension in a liquid by movement of the liquid induced by a vertically reciprocating paddle. The tips of needles in an array are immersed in the suspension, a slot being provided in the paddle to avoid collision with the needles. Liquid is drawn into the needles until a bead becomes attached to the tip of each needle. Excess beads adhering to the needles are shaken off by an electromagnetically operated vibrator, and the beads are deposited in wells of a well plate by applying a short burst of pressure to the interiors of the needles. Liquid and any debris within the needles are thereafter discharged to a receptacle by applying a higher pressure burst to the interiors of the needles.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jack Dale Leber, Brian E. Lock
  • Endothelin receptor antagonists
    Patent number: 6087389
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: July 11, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Patent number: 6075037
    Abstract: Pyrrolo[2,3-b]pyridine derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: June 13, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Jack Dale Leber
  • Apparatus and process for arraying beads
    Patent number: 5935859
    Abstract: A mixture of beads from a combinatorial library is held in suspension either by inducing circulating flow of a liquid in a tapered vessel by rising air bubbles or by floating the beads at the interface between two immiscible liquids. Beads are selected individually from the suspension by drawing liquid into the tip of a needle having a circular opening smaller than the diameter of a bead. After a bead is captured on the tip of a needle, excess beads are jarred loose or washed away by flow of a solvent through a sheath surrounding the needle, and the needle is moved by a robotic manipulator to a well into which the bead is released.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: August 10, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, John Gerald Gleason, Jack Dale Leber, Gerald C. Simolike
  • Endothelin receptor antagonists
    Patent number: 5834469
    Abstract: The invention concerns compounds of the following formulae: ##STR1## wherein the variables are defined in the specification. The compounds are useful as endothelin receptor antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Jack Dale Leber
  • Endothelin receptor antagonists
    Patent number: 5817693
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: October 6, 1998
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Patent number: 5719183
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor anatagonists
    Patent number: 5719182
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Endothelin receptor antagonists
    Patent number: 5686481
    Abstract: Indole derivatives of formula (1) wherein the substituents are defined herein are disclosed. The compounds are useful in methods of antagonizing endothelin receptors, treating hypertension, treating renal failure and treating cerebrovascular disease. Pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: November 11, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Jack Dale Leber