Abstract: Devices and methods for improvement of functioning of a valve of a subject are disclosed. A device exhibiting an outward bias at its proximal end and an outward bias at its distal end, disposed at an angle to the bias at the proximal end is described. A device having a first arm and a second arm separated by a peak and having shoulders is also described. Alternative embodiments which function to decrease the distance between valve leaflets, having a first arm and a second arm biased toward one another are also disclosed. Several embodiments which may have mirror image ends are also disclosed. Any of the devices may have barbs, umbrella structures, sutures, or a variety of spring elements. Devices may be implanted surgically, percutaneously or subcutaneously. Methods and devices for delivery and deployment of devices are disclosed as well as methods for treatment of a valve of a subject.

Abstract: A minimally invasive method that allows for complete obliteration of the affected vessels without scarring or any of the other undesirable complications of conventional or foam sclerotherapy. More particularly, the present invention relates to a method for using a non-foaming thickener to reduce dilution and diffusion of the sclerosant in the blood vessel and enhance the efficacy of the sclerotherapy treatment. The thickener can be thickening agent, hydrogel, environmentally sensitive hydrogel, and self-assembly polymer, etc. After it is mixed with sclerosant and injected into the blood vessel through a needle or a catheter, the compound will replace blood and obliterate the affected vessels.