Patents by Inventor Jack Greenblatt

Jack Greenblatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for systematic identification of protein—protein interactions
    Patent number: 6797523
    Abstract: The present invention relates to a method for identifying protein—protein interactions. The interacting proteins are isolated by affinity chromatography and identified by mass spectrometry. The affinity chromatography method allows for the purification of unknown interacting proteins which are identified using mass spectrometric techniques. The invention provides a method for the high throughput analysis of protein—protein interactions that lends itself to automation.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: September 28, 2004
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Donald E. Awrey, Jack Greenblatt
  • Methods for gene disruption and uses thereof
    Publication number: 20030082591
    Abstract: The present invention relates to compositions and methods for in-frame disruption of a gene sequence by homologous recombination. The present invention may be used in certain embodiments to disrupt a gene without causing any downstream effects on non-target sequences. In certain embodiments, the inventive methods may be used to identify and/or characterize products encoded by essential genes, conditionally essential genes, and non-essential genes.
    Type: Application
    Filed: July 24, 2002
    Publication date: May 1, 2003
    Inventors: Donald Awrey, Jack Greenblatt
  • Multi-target analysis of gene families for chemistry of high affinity and selective small molecules and other therapeutics
    Publication number: 20030068651
    Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.
    Type: Application
    Filed: March 12, 2002
    Publication date: April 10, 2003
    Inventors: Cheryl Arrowsmith, Jack Greenblatt, Aled Edwards, John D. Mendlein
  • Target analysis for chemistry of specific and broad spectrum anti-infectives and other therapeutics
    Publication number: 20030068650
    Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.
    Type: Application
    Filed: March 12, 2002
    Publication date: April 10, 2003
    Inventors: Jack Greenblatt, Aled Edwards, Cheryl Arrowsmith, John D. Mendlein
  • Proteins and druggable regions of proteins
    Publication number: 20030068831
    Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.
    Type: Application
    Filed: March 12, 2002
    Publication date: April 10, 2003
    Inventors: Aled Edwards, Cheryl Arrowsmith, Jack Greenblatt, John D. Mendlein
  • Methods for systematic identification of protein - protein interactions
    Publication number: 20020102741
    Abstract: The present invention relates to a method for identifying protein-protein interactions. The interacting proteins are isolated by affinity chromatography and identified by mass spectrometry. The affinity chromatography method allows for the purification of unknown interacting proteins which are identified using mass spectrometric techniques. The invention provides a method for the high throughput analysis of protein-protein interactions that lends itself to automation.
    Type: Application
    Filed: November 30, 2000
    Publication date: August 1, 2002
    Inventors: Donald E. Awrey, Jack Greenblatt