Abstract: The present invention relates to an enzymatically generated iodine microbicide for the inactivation of pathogenic organisms that are contaminants in or on sensitive biological materials such as the human eye. The biocidal agent from the enzymatic reaction is free molecular iodine which is generated at a minimum level of 5 ppm and comprises at least 25% of the total iodine species present on a molar basis.

Abstract: The present invention relates generally to an enzymatically generated iodine microbiocide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that are contaminants in sensitive biological materials. The biocidal agent from the enzymatic reaction is free molecular iodine generated so as to (1) establish a minimum level above 10 ppm of free molecular iodine and (2) to establish defined ratios of free molecular iodine to other iodine species such that free molecular iodine comprises at least 10% of the total iodine species present on a molar basis.

Abstract: The present invention relates generally to an enzymatically generated iodine microbicide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that are contaminants in or on sensitive biological materials such as the human eye or tissue culture cells. The biocidal agent from the enzymatic reaction is free molecular iodine generated so as to establish a minimum level of 5 ppm in a fashion such that free molecular iodine comprises at least 25% of the total iodine species present on a molar basis.

Abstract: Germicidal iodine based compositions are disclosed that consist of iodide anions, a source of peroxide and peroxidase in combination with iodine sequestering agents. The compositions are formed in situ in an aqueous based medium by combining a peroxide source, iodine ions or source thereof, a peroxidase classified within Enzyme Commission identification No. E.C. 1.11.1.7 and an iodine sequestrant. The addition of a sequestrant before the equilibration of the enzymatic reaction formed by admixing the composition with an aqueous based medium, provides for a non-reactive enzymatic composition. The resulting composition having an increase of available iodine concentration compared to an identical composition without an iodine sequestrant.

Abstract: This invention relates to a viscous epidermal cleaner and disinfectant using peroxidase, peroxide, an iodide compound, surfactants and buffering agents to control the pH when admixed in water for forming a viscous composition with a pH between 3.0 and 6.5 and a viscosity of not less than 1.2 centipoise. The active components are maintained inactive until admixed in a defined proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5. Alternatively, all of the components of this application can be shipped as dry powders or tablets and dissolved prior to use to yield a viscous aqueous environment that will be applied to the epidermis with no further dilution.

Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a define proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.

Abstract: A method for the simultaneous cleaning and disinfecting of contact lenses based upon the combined use of a proteolytic enzyme for cleaning and a peroxidative enzymatic reaction with donor and acceptor molecules and a thiol agent for color control.

Abstract: This invention relates to a color controlled disinfecting peroxide cold sterilization composition employing an iodide salt and to a method for controlling the formation and duration of color when such composition is combined with water.

Abstract: An enzymatic sterilization system is disclosed which is effective against viruses and other organisms. Methods are disclosed to increase the rate of and reduce the cost for sterilization with this chemistry as compared to the prior art. Methods are disclosed to formulate a sterlizing chemistry which actively maintains a sterile environment over a defined period of time.

Abstract: The method comprises forming a sporocide having a defined period of sporocidal activity comprising three components including a peroxide or peroxide generating material, a peroxidase and a salt of iodide which serves as a donor molecule; storing the three components in a nonreacting state to maintain the sporocide in an inactive state and admixing the three components in a aqueous based carrier to cause a catalyzed reaction by said peroxidase for generating free radicals and/or byproducts from the iodide salt (donor molecule) and contacting the surface or object to be sterilized with the activated mixture. The concentration level of the three components can be selected such that an active sporocidal state is maintained for any desired period of time.

Abstract: The method comprises forming a bactericide having a limited period of bacteriological activity with the bactericide comprising three components including a peroxide, a peroxidase and a source of donor molecules adopted to act as a substrate for the peroxidase; storing the three components in a nonreacting state to maintain the bactericide inactive and admixing the three components in a liquid carrier to cause a catalyzed reaction by said peroxidase for generating free radicals from the source of donor molecules and immersing the contact lens into the solution simultaneously with the admixture. The concentration level of the three components should be selected such that a substantial portion of the peroxide is consumed during the catalyzed reaction.

Abstract: The bactericidal method of the invention comprises forming a bactericide having a limited period of bacteriological activity with the bactericide including; a peroxide, a peroxidase and a source of donor molecules adapted to act as a substrate for said peroxidase; activating the bactericide to cause a catalyzed reaction by said peroxidase for generating free radicals from said source of donor molecules and simultaneously applying the bactericide for killing bacteria in the treatment of dental disease in situ such as in the oral cavity or as a denture cleaner.

Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a .[.define.]. .Iadd.defined .Iaddend.proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.