Patents by Inventor Jack Koehl

Jack Koehl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)
    Publication number: 20050054631
    Abstract: The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 10, 2005
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: John Jiang, Jack Koehl, Shujaath Mehdi, Neil Moorcroft, Kwon Musick, Philip Weintraub, Paul Eastwood