Patents by Inventor Jack L. Nichols

Jack L. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of screening physiological samples for elevated levels of heat shock proteins
    Patent number: 5807690
    Abstract: METHOD OF SCREENING PHYSIOLOGICAL SAMPLES for elevated levels of heat shock proteins due to chronic exposure to sublethal levels of stressors, and kits for carrying out the method, are disclosed.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: September 15, 1998
    Assignees: StressGen Biotechnology Corporation, CA. State University, Long Beach Foundation
    Inventors: Brenda M. Sanders, Kenneth D. Jenkins, Jack L. Nichols, Bryan E. Imber
  • Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of stressors
    Patent number: 5780246
    Abstract: Method of detecting chronic exposure of an organism to a stressor, and for evaluating biological damage due to chronic exposure to sublethal levels of stressors and kits for carrying out the method are disclosed. The methods comprise: (a) sampling at least one organism in order to determine whether it has been chronically exposed to a sublethal concentration of one or more stressors in its environment, under sampling conditions that do not induce any additional heat shock protein (hsp) response in the organism; (b) obtaining a sample of cells or secretions of said organism, suspected of having elevated levels of heat shock proteins and solubilizing the heat shock proteins in the sample; and (c) measuring the concentration of a heat shock protein in said sample.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: July 14, 1998
    Assignees: StressGen Biotechnology Corporation, CA. State University, Long Beach Foundation
    Inventors: Brenda M. Sanders, Kenneth D. Jenkins, Jack L. Nichols, Bryan E. Imber
  • Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
    Patent number: 5464750
    Abstract: Method of detecting chronic exposure of an organism to a pollutant, and for evaluating biological damage due to chronic exposure to sublethal levels of pollutants and kits for carrying out the method are disclosed. The methods comprise:(a) sampling at least one organism in order to determine whether it has been chronically exposed to a sublethal concentration of one or more pollutants in its environment, under sampling conditions that do not induce any additional heat shock protein (hsp) response in the organism;(b) obtaining a sample of cells or secretions of said organism, suspected of having elevated levels of heat shock proteins and solubilizing the heat shock proteins in the sample; and(c) measuring the concentration of a heat shock protein in said sample.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: November 7, 1995
    Assignees: StressGen Biotechnology Corporation, Ca. State University Long Beach Foundation
    Inventors: Brenda M. Sanders, Kenneth D. Jenkins, Jack L. Nichols, Bryan E. Imber
  • Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
    Patent number: 5232833
    Abstract: Method of detecting chronic exposure of an organism to a pollutant, and for evaluating biological damage due to chronic exposure to sublethal levels of pollutants and kits for carrying out the method are disclosed. The methods comprise:(a) sampling at least one organism in order to determine whether it has been chronically exposed to a sublethal concentration of one or more pollutants in its environment, under sampling conditions that do not induce any additional heat shock protein (hsp) response in the organism;(b) obtaining a sample of cells or secretions of said organism, suspected of having elevated levels of heat shock proteins and solubilizing the heat shock proteins in the sample; and(c) measuring the concentration of a heat shock protein selected from hsp 70, hsp 60 and ubiquitin, in said sample.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: August 3, 1993
    Assignee: Stressgen Biotechnologies Corporation
    Inventors: Brenda M. Sanders, Kenneth D. Jenkins, Jack L. Nichols, Bryan E. Imber