Abstract: An apparatus (foam-lined cassette) to cradle and support the cryo-bag during control rate freezing, storage, shipping, throughout the cold-chain, and in the event of a drop or impact during handling. The cassette lid is at the top of the apparatus, lined with a foam pad capable of withstanding cryogenic temperatures. The lower body of the apparatus is also lined and includes an internal pocket made of the same cryogenically compatible foam material where the cryo-bag can be inserted and cradled snugly. The internal pocket makes a “sandwich” type configuration to prevent any movement of the sample once the cassette is locked, shields the cryo-bag from contacting the hard shell of the cassette, and absorbs any impact forces realized during handling or dropping of the cassette.