Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The disclosure is directed towards the real-time detection and mitigation of security threats to a domain name system (DNS) for a communication network. A graph-theoretic method is applied to detect compromised DNS assets (e.g., DNS servers and web servers that DNS servers map domain names to). A graph is generated from domain name resolution (DNR) transactions. The nodes of the graph represent the DNS assets and edges between the nodes represent the DNR transactions. The graph is analyzed to detect features that signal compromised assets. The detection of such features serves to act as a binary classifier for the represented assets. The binary classifier acts to classify each node as non-compromised or compromised. The analysis is guided by supervised and/or unsupervised machine learning methods. Once the assets are classified, DNR transactions are analyzed in real-time. If the transaction involves a compromised asset, an intervention is performed that mitigates the threat.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A cooking appliance having a cabinet including an insert within the cabinet to define cooking chamber with an access opening and a door selectively closing/opening the access opening, the cooking appliance comprising at least one of a first cooling flow path through a back wall of the cabinet, over a top wall of the insert, and out a side wall of the cabinet, a second cooling flow path through a bottom wall of the cabinet, along the bottom wall of the cabinet, and out a side wall of the cabinet, and a third cooling flow path through a bottom wall of the cabinet, out a front wall of the cabinet, into the door, out of the door, into a front wall of the cabinet, and out of a side wall of the cabinet.

Abstract: An automatic oven having a controller and a sensor assembly for automatically determining a food type for a food item placed in a cooking chamber of the automatic oven, and cooks the automatically determined food item according to a cooking profile selected based on the determined food type, while optionally accommodating a user input on the determining of the food type, and the cooking profile, including an optional degree of doneness.

Abstract: The present disclosure is directed to compounds of Formula IV: as inhibitors of SHP2 and their use in the treatment of diseases associated with SHP2. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure provides monitoring system, device and computed-implemented method for monitoring pressure ulcers. The monitoring system and the device are configured to: capture at least one image corresponding to a user; retrieve the anamnesis data of the user; and determine a pressure ulcers condition result corresponding to the at least one image and the anamnesis data according a pressure ulcers prediction model.

Abstract: A vehicle includes a body, a removable cab, a cargo movement subsystem, and a computing device. The removable cab is attachable to the body. The computing device includes a processor and a memory. The computing device is programmed to actuate at least one vehicle subsystem to move the vehicle to deliver cargo stored in the cab and the cargo movement subsystem move the cargo. The cargo movement subsystem is arranged to move the cargo from the cab to a position accessible from an exterior of the vehicle.

Abstract: A scooter includes a platform, a shell movably coupled to the platform via a gripper of the shell and a grip surface of the platform, and front and rear wheels rotatably coupled to the platform. The shell defines a cavity, and the platform is movable into and out of the cavity. The scooter may include a retractable pole coupled to the platform and a handlebar coupled to the retractable pole. The retractable pole may be coupled to and steer the front wheel. The shell may include one or two foldable decks.

Abstract: An automatic oven having a controller and a sensor assembly for automatically determining a food type for a food item placed in a cooking chamber of the automatic oven, and cooks the automatically determined food item according to a cooking profile selected based on the determined food type, while optionally accommodating a user input on the determining of the food type, and the cooking profile, including an optional degree of doneness.

Abstract: The present disclosure provides monitoring system, device and computed-implemented method for monitoring pressure ulcers. The monitoring system and the device are configured to: capture at least one image corresponding to a user; retrieve the anamnesis data of the user; and determine a pressure ulcers condition result corresponding to the at least one image and the anamnesis data according a pressure ulcers prediction model.

Abstract: An automatic oven having a controller and a sensor assembly for automatically determining a food type for a food item placed in a cooking chamber of the automatic oven, and cooks the automatically determined food item according to a cooking profile selected based on the determined food type, while optionally accommodating a user input on the determining of the food type, and the cooking profile, including an optional degree of doneness.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A scooter includes a platform, a shell movably coupled to the platform via a gripper of the shell and a grip surface of the platform, and front and rear wheels rotatably coupled to the platform. The shell defines a cavity, and the platform is movable into and out of the cavity. The scooter may include a retractable pole coupled to the platform and a handlebar coupled to the retractable pole. The retractable pole may be coupled to and steer the front wheel. The shell may include one or two foldable decks.

Abstract: Mobile client device wireless charging, communication, and authentication techniques are described. In one or more implementations, a method performed by a mobile client device includes establishing wireless communication with a substrate having an integrated electromagnetic inductive coil in accordance with the mobile client device being at a distance proximal to the substrate to achieve an inductive connection. After establishing the wireless communication, the method includes receiving wireless inductive power from the substrate, establishing communication with a device via the wireless communication with the substrate, and after establishing communication with the device, operating, via the wireless communication, as a user input device for the device by outputting a user interface on a display device of the mobile client device, the user interface being operable to receive user input for the device.

Abstract: A personal transportation device comprises a frame, a wheel pivotably connected to a frame and switchable between a driving configuration and a flying configuration, a motor to rotate the wheel; and an automatic cruise module. The automatic cruise module is configured to control the wheel and guide the personal transportation device to fly from a first location to a second location according to a designated route as an unmanned aircraft.