Patents by Inventor Jack Liang

Jack Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
    Patent number: 8178333
    Abstract: The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate
    Patent number: 8088610
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: January 3, 2012
    Assignee: Codexis, Inc.
    Inventors: Jack Liang, Birthe Borup, Vesna Mitchell, Emily Mundorff, James LaLonde, Gjalt W. Huisman
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE
    Publication number: 20110217754
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
    Type: Application
    Filed: May 18, 2011
    Publication date: September 8, 2011
    Applicant: CODEXIS, INC.
    Inventors: Jack Liang, Stephane J. Jenne, Emily Mundorff, Rama Voladri, James LaLonde, Gjalt W. Huisman
  • Ketoreductase polypeptides for the production of ()-3-hydroxythiolane
    Patent number: 7977078
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
    Type: Grant
    Filed: August 24, 2008
    Date of Patent: July 12, 2011
    Assignee: Codexis, Inc.
    Inventors: Jack Liang, Stephane J. Jenne, Emily Mundorff, Rama Voladri, James Lalonde, Gjalt Huisman
  • BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
    Publication number: 20100063300
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: June 23, 2009
    Publication date: March 11, 2010
    Applicant: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Ketoreductase Polypeptides for the Reduction of Acetophenones
    Publication number: 20090191605
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: September 13, 2008
    Publication date: July 30, 2009
    Applicant: CODEXIS, INC.
    Inventors: Jack Liang, Stephane J. Jenne, Emily Mundorff, Charlene Ching, John M. Gruber, Anke Krebber, Gjalt W. Huisman
  • KETOREDUCTASE POLYPEPTIDES AND USES THEREOF
    Publication number: 20090155863
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: September 29, 2008
    Publication date: June 18, 2009
    Applicant: CODEXIS, INC.
    Inventors: JACK LIANG, BIRTHE BORUP, VESNA MITCHELL, EMILY MUNDORFF, JAMES LALONDE, GJALT W. HUISMAN
  • Ketoreductase Polypeptides for the Production of (R)-3-Hydroxythiolane
    Publication number: 20090093031
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
    Type: Application
    Filed: August 24, 2008
    Publication date: April 9, 2009
    Applicant: CODEXIS, INC.
    Inventors: Jack Liang, Stephane J. Jenne, Emily Mundorff, Rama Voladri, James Lalonde, Gjalt W. Huisman
  • Substituted phenylacetic acids
    Publication number: 20060264630
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Application
    Filed: January 4, 2006
    Publication date: November 23, 2006
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Liang
  • Alpha(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
    Publication number: 20050222213
    Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: October 6, 2005
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Liang
  • Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
    Patent number: 6911544
    Abstract: The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine and (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: June 28, 2005
    Assignees: Pfizer Inc., DSM Pharmaceuticals, Inc.
    Inventors: Robert Seemayer, Thomas C. Nugent, Jack Liang
  • Method of planarization of semiconductor devices
    Patent number: 6908361
    Abstract: A method of planarizing a semiconductor device includes the steps of providing a semiconductor substrate, forming a semiconductor component over the semiconductor substrate, depositing a doped silicate glass layer over the semiconductor component using a high density plasma chemical vapor deposition, the doped silicate glass layer forming a protrusion directly over the semiconductor component, and planarizing the doped silicate glass layer by a chemical mechanical polishing process to remove the protrusion.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: June 21, 2005
    Assignee: Winbond Electronics Corporation
    Inventors: Shao-Yu Ting, Jack Liang, Chih-Fan Wang
  • Process for the preparation of (S,S)-CIS-2-phenyl-3-aminopiperidine
    Publication number: 20040110953
    Abstract: The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine and (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
    Type: Application
    Filed: October 9, 2003
    Publication date: June 10, 2004
    Applicants: PFIZER INC., DSM PHARMACEUTICALS, INC.
    Inventors: Robert Seemayer, Thomas C. Nugent, Jack Liang
  • Synthesis of spiro esters, spiro ortho carbonates, and intermediates
    Patent number: 6734313
    Abstract: Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: May 11, 2004
    Assignee: Bioavailability Systems, LLC
    Inventors: Robert Seemayer, Jack Liang
  • Method of planarization of semiconductor devices
    Publication number: 20040048480
    Abstract: A method of planarizing a semiconductor device includes the steps of providing a semiconductor substrate, forming a semiconductor component over the semiconductor substrate, depositing a doped silicate glass layer over the semiconductor component using a high density plasma chemical vapor deposition, the doped silicate glass layer forming a protrusion directly over the semiconductor component, and planarizing the doped silicate glass layer by a chemical mechanical polishing process to remove the protrusion.
    Type: Application
    Filed: September 10, 2002
    Publication date: March 11, 2004
    Inventors: Shao-Yu Ting, Jack Liang, Chih-Fan Wang
  • Synthesis of spiro esters, spiro ortho carbonates, and intermediates
    Publication number: 20040002611
    Abstract: Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
    Type: Application
    Filed: May 9, 2003
    Publication date: January 1, 2004
    Applicant: BIOAVAILABILITY SYSTEMS, LLC
    Inventors: Robert Seemayer, Jack Liang
  • Method for manufacturing semiconductor devices having copper interconnect and low-K dielectric layer
    Patent number: 6638849
    Abstract: A dual damascene process for forming semiconductor devices containing a copper interconnect and a low-K dielectric layer on a wafer which allows the copper interconnect to be formed subsequent to the formation of the low-K dielectric layer while preventing the low-K dielectric layer from being degraded by a subsequent plasma etching.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: October 28, 2003
    Assignee: Winbond Electronics Corp.
    Inventors: Shao-Yu Ting, Jack Liang, Kuo-Ju Liu
  • Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
    Patent number: 6613918
    Abstract: Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: September 2, 2003
    Assignee: Bioavailability Systems, LLC
    Inventors: Robert Seemayer, Jack Liang
  • Method for manufacturing semiconductor devices having copper interconnect and low-K dielectric layer
    Publication number: 20020192937
    Abstract: A dual damascene process for forming semiconductor devices containing a copper interconnect and a low-K dielectric layer on a wafer which allows the copper interconnect to be formed subsequent to the formation of the low-K dielectric layer while preventing the low-K dielectric layer from being degraded by a subsequent plasma etching.
    Type: Application
    Filed: January 7, 2002
    Publication date: December 19, 2002
    Inventors: Shao-Yu Ting, Jack Liang, Kuo-Ju Liu
  • Method for forming a film over a spin-on-glass layer by means of plasma-enhanced chemical-vapor deposition
    Patent number: 5792702
    Abstract: A method for forming an oxide film over a spin-on-glass (SOG) layer by a plasma-enhanced chemical-vapor deposition (PECVD) is disclosed. The SOG layer is pre-processed in a forming gas of hydrogen and nitrogen in a PECVD chamber. Then the oxide film is formed over the SOG layer by means of the PECVD process in the PECVD chamber.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: August 11, 1998
    Assignee: Winbond Electronics Corp.
    Inventor: Jack Liang