Abstract: A method and apparatus for initiating a positive-pressure-assisted inspiration phase in response to a patient's inspiratory effort, and independently of the absolute pressure at the time of the inspiratory effort, since the absolute pressure may vary from patient to patient or depend upon a particular mode of operation of the respiration system. The invention apparatus includes a differentiator circuit for obtaining a time-differentiated pressure signal, and a circuit for detecting a change in the sign of the slope of the differentiated signal. The patient's inspiratory effort is manifested as an increased rate of pressure drop, and this shows up as a change in the sign of the slope of the differentiated pressure, which is detected independently of absolute pressure, and is utilized to initiate an assisted inspiration phase.