Patents by Inventor Jack Mathew Webster

Jack Mathew Webster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two helix binders
    Patent number: 7772363
    Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: August 10, 2010
    Assignee: General Electric Company
    Inventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
  • TWO HELIX BINDERS
    Publication number: 20100047923
    Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.
    Type: Application
    Filed: December 18, 2008
    Publication date: February 25, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
  • TWO HELIX BINDERS
    Publication number: 20100041073
    Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
    Type: Application
    Filed: December 18, 2008
    Publication date: February 18, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Joshua Kendall Hoerner, Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
  • TWO HELIX BINDERS
    Publication number: 20100035361
    Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
    Type: Application
    Filed: December 18, 2008
    Publication date: February 11, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
  • TWO HELIX BINDERS
    Publication number: 20090325313
    Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
    Type: Application
    Filed: December 18, 2008
    Publication date: December 31, 2009
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
  • TWO HELIX BINDERS
    Publication number: 20080176278
    Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.
    Type: Application
    Filed: December 8, 2006
    Publication date: July 24, 2008
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Faisal Ahmed Syud, Jack Mathew Webster