Abstract: The activity state classification method of the present invention employs a kernel-based modeling technique, and more specifically a set of similarity-based models, which have been created using example data, to process an input observation or set of input observations, each comprising a set of sensor readings or “features” derived there from or other data, to predict the activity state of a person from whom the sensor data was obtained. A model is created for each class of activity. The input data is processed by each model and the resulting predictions are combined to yield a final prediction of which state of activity is represented by the input data.

Abstract: An analytic apparatus and method is provided for diagnosis, prognosis and biomarker discovery using transcriptome data such as mRNA expression levels from microarrays, proteomic data, and metabolomic data. The invention provides for model-based analysis, especially using kernel-based models, and more particularly similarity-based models. Model-derived residuals advantageously provide a unique new tool for insights into disease mechanisms. Localization of models provides for improved model efficacy. The invention is capable of extracting useful information heretofore unavailable by other methods, relating to dynamics in cellular gene regulation, regulatory networks, biological pathways and metabolism.