Abstract: Compositions and methods are described herein that can reduce the frequency and/or severity of gastroesophageal reflux disease (GERD). Such compositions and methods can include use of maltosyl-isomaltooligosaccharides with or without one or more proton pump inhibitors, one or more potassium-competitive acid blockers, one or more H-2 antagonists, one or more antiacids, one or more bile acid sequestrants, one or more prokinetic agents, one or more dopamine receptor antagonists, one or more coating agents (protectants), one or more antibiotics, one or more probiotics, or a combination thereof.