Patents by Inventor Jack R. Collins

Jack R. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
    Patent number: 7749984
    Abstract: A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: July 6, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Irving W. Wainer, Krzysztof Jozwiak, Ruin Moaddel, Sarangan Ravichandran, Jack R. Collins
  • Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
    Publication number: 20040204862
    Abstract: A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
    Type: Application
    Filed: April 11, 2003
    Publication date: October 14, 2004
    Inventors: Irving W. Wainer, Krzysztof Jozwiak, Sarangan Ravichandran, Jack R. Collins
  • Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses
    Patent number: 5525621
    Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined in the disclosure. The compounds are particularly useful for inhibiting damage to a variety of mammalian tissue that are jeopardized, for example, during runaway inflammatory conditions due to the damaging presence of singlet oxygen, the hydroxyl radical, cytokines and growth factors. The compounds are also useful in inhibiting damage to cardiac and central nervous system tissues during reperfusion.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 11, 1996
    Assignee: Cytos Pharmaceuticals LLC
    Inventors: Stanley Burt, Jack R. Collins