Patents by Inventor Jack Silver

Jack Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5104865
    Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: April 14, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4912118
    Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroypyrid-4-one or 1-hydropyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficien
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: March 27, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4894455
    Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydro
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: January 16, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4840958
    Abstract: Pharmaceutical compositions containing a 3-hydroxyprid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or a salt thereof containing a physiologically acceptable cation, are of value for removing toxic amounts of metals, particularly iron, from the body. These compositions are useful in the treatment of iron overloads.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: June 20, 1989
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
  • Patent number: 4775227
    Abstract: An electrochromic device consists of the layers: tin-oxide-coated glass; rare earth diphthalocyanine (REDPC); membrane electrolyte; REDPC; tin-oxide-coated glass. The REDPC is the electrochromic layer and contains a mixture of rare earths as obtained from a natural deposit without being individually separated. The REDPC is preheated to purify it and then sublimed into position as the device is assembled.The device is driven by a controller which is limited to the voltage range +2V to -1V, whereby only the colors red, green and blue are obtainable, that is, although the REDPC at -1.5V would show purple, this is deliberately foregone to prolong its life.The REDPC may be further mixed with tin phthalocyanine chloride or ruthenium, iron, zinc or cobalt phthalocyanine.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: October 4, 1988
    Assignee: National Research Development Corporation
    Inventor: Jack Silver
  • Patent number: 4666927
    Abstract: Compounds in which two or more rings, being a 3-hydroxypypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.
    Type: Grant
    Filed: September 18, 1984
    Date of Patent: May 19, 1987
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4665064
    Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydro
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: May 12, 1987
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4650793
    Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: March 17, 1987
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4587240
    Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of val
    Type: Grant
    Filed: September 18, 1984
    Date of Patent: May 6, 1986
    Assignee: National Research Development Corp.
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 4585780
    Abstract: Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron,
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: April 29, 1986
    Assignee: National Research Development Corp.
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
  • Patent number: 4550101
    Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are also replaced by an aliphatic hydrocarbon group, are of value for the treatment of iron deficiency anemia.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: October 29, 1985
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: RE34313
    Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of val
    Type: Grant
    Filed: October 1, 1991
    Date of Patent: July 13, 1993
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham