Abstract: A quick release assembly including a pair of flanges for receiving a rupture disc insert type holder and the like therebetween in a leak-tight seal, at least one of the flanges being secured to a pressure relief conduit of a pressure system. A minimum number of bolts, preferably a maximum of three Jack-type bolts, secure the two flanges together to provide a quick access to the rupture disc insert type holder disposed between the flanges for replacement or inspection of the rupture disc contained within the insert type holder, where the Jack-type bolts spread the two flanges apart. Stop pins are provided on at least one of the flanges to position the insert type holder between the two flanges. Preferably, one of the flanges is slotted, and the other flange has threaded openings therethrough to receive the Jack-type bolts to provide for a quick release spreading of the flanges apart, each Jack-type bolt being provided with a positioning collar thereon.