Abstract: According to a first aspect disclosed herein there is provide a device comprising: a PUF module, and one or more outer layer components providing at least part of an unsecured channel for inputting a challenge to the PUF module and receiving back a response. Internal logic of the PUF module comprises a logging mechanism arranged to automatically log a record of the challenge and/or response in a log medium, e.g. a blockchain. According to a second aspect, there is provided a method comprising: sending a first message to be recorded on a blockchain, submitting a query to check that the first message has been recorded on the blockchain without manipulation, on condition thereof, sending a second messaging transaction to be recorded on the blockchain. The first and second aspects may be used together or independently.

Abstract: The examples described herein relate to a coffee bean package assembly including: a package body having: a receiving aperture defined therein to receive coffee beans into an interior of the package body during a filling operation, and a dispensing aperture defined therein to dispense the coffee beans from the interior of the package body during a dispensing operation; a closing mechanism to close the receiving aperture of the package body; a rigid support member secured around the dispensing aperture within the package body; a grinding mechanism to operationally receive coffee beans, via the dispensing aperture, from the interior of the package body during the dispensing operation, the grinding mechanism having an electric motor; a battery electrically coupled to the electric motor of the grinding mechanism; and a solar panel securable to the package body, and electrically couplable to the battery to enable charging of the battery.

Abstract: Some examples described herein include coffee bean packaging assemblies that integrate a packaging body with a grinding mechanism (e.g., a burr grinder). The example coffee bean assemblies described provide storage advantages (e.g., coffee beans and grinders do not need to be separately stored and located when wanting to dispense freshly ground coffee), as well as travel advantages (e.g., a separate coffee grinder does not need to be remembered packed when traveling).

Abstract: Some examples described herein include coffee bean packaging assemblies that integrate a packaging body with a grinding mechanism (e.g., a burr grinder). The example coffee bean assemblies described provide storage advantages (e.g., coffee beans and grinders do not need to be separately stored and located when wanting to dispense freshly ground coffee), as well as travel advantages (e.g.

Abstract: Methods are provided for authenticating a value article that includes a luminescent material. An exciting light source, an optical filter, a photodetector, a signal manipulation circuit, and an amplifier are provided. The luminescent material is exposed to light produced by the exciting light source. Radiation including light from the exciting light source and emitted radiation from the luminescent material is filtered using the optical filter to produce filtered radiation. The filtered radiation is detected using the photodetector to produce a detected radiation signal. The detected radiation signal is electronically manipulated using the signal manipulation circuit to reduce an effect of light from the exciting light source on an authentication determination based upon the detected radiation signal. The detected radiation signal is amplified with the amplifier after electronic manipulation to produce an amplified electronic signal.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: Methods are provided for authenticating a value article that includes a luminescent material. An exciting light source, an optical filter, a photodetector, a signal manipulation circuit, and an amplifier are provided. The luminescent material is exposed to light produced by the exciting light source. Radiation including light from the exciting light source and emitted radiation from the luminescent material is filtered using the optical filter to produce filtered radiation. The filtered radiation is detected using the photodetector to produce a detected radiation signal. The detected radiation signal is electronically manipulated using the signal manipulation circuit to reduce an effect of light from the exciting light source on an authentication determination based upon the detected radiation signal. The detected radiation signal is amplified with the amplifier after electronic manipulation to produce an amplified electronic signal.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.

Abstract: Embodiments include methods and apparatus for identifying a thermographic phosphor (e.g., Er:YIG) incorporated on or within an article. The method and apparatus embodiments include an excitation energy generator selectively exposing the article to excitation energy in an absorption band of the thermographic phosphor. An emitted radiation detector detects first emission characteristics of first emitted radiation from the article within an emission band of the thermographic phosphor when the article has a first temperature, and detects second emission characteristics of second emitted radiation from the article within the emission band when the article has a second temperature that is different from the first temperature. A temperature adjustment element is configured to adjust the temperature of the article. Embodiments further include a processing system determining whether the first emission characteristics are sufficiently different from the second emission characteristics.

Abstract: The invention provides improved agents and methods for treatment of diseases associated with beta amyloid (A?). Preferred agents include antibodies, e.g., humanized antibodies specific for A?.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: An emulsion composition comprising (1) a compound (I) represented by the formula (I) wherein each symbol is as defined in the specification (2) an anionic synthetic phospholipid in a proportion of about 0.0001 about 5% (W/V) relative to the composition in total, and (3) a naturally-occurring phospholipid in a proportion of about 0.1 about 10% (W/V) relative to the composition in total is provided.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A? in the brain of a patient. Preferred agents include antibodies, e.g., humanized antibodies.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: An emulsion composition comprising (1) a compound (I) represented by the formula (I) wherein each symbol is as defined in the specification (2) an anionic synthetic phospholipid in a proportion of about 0.0001 about 5% (W/V) relative to the composition in total, and (3) a naturally-occurring phospholipid in a proportion of about 0.1 about 10% (W/V) relative to the composition in total is provided.

Abstract: The present invention addresses a need in the art for methods of identifying apoptotic proteins and methods for screening compounds which inhibit an apoptotic protein. More particularly, in certain embodiments, the invention relates to increased expression levels of a NALP1 gene and/or a NALP5 gene following neuron injury. In other embodiments, the present invention demonstrates that the recombinant expression of NALP1 and/or NALP5 polynucleotides stimulates apoptosis in cultured neurons, HeLa cells and NIH-3T3 cells. In yet other embodiments, the invention relates to mutations in the nucleotide binding sequence (NBS) of a NALP1 or a NALP5 polypeptide, wherein these NBS mutations inhibit purine nucleotide binding and reduce caspase activation.

Abstract: The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.