Abstract: The present invention relates to highly porous, bioresorbable electrospun sensors for optical detection of tissue oxygenation and processes of making and using same. Multiple sensor compositions are described that are focused on different applications/oxygen ranges. Such sensors alleviate the risk of leaving the sensor implanted in a subject, typically have as good or better oxygen sensing capabilities and comparable performance life span as non-degradable sensors and unlike sensors made from general bioresorbable materials maintain a desired porosity as they degrade. Thus, such sensors may remain integrated in a subject's body while they degrade and maintain the ability to sense oxygen for their performance life span.

Abstract: A sensor system for optical detection of multiple analytes is discussed. An example system is presented that includes a plurality of lenses configured to receive individual light signals from analyte-sensing chromophores disposed on an array when the analyte-sensing chromophores are illuminated by light while being exposed to different specific analytes within an interstitial fluid. The system further includes at least one volume phase grating (VPG) communicatively coupled to at least one of the plurality of lenses and a detector communicatively coupled to the at least one VPG so that light signals from the analyte-sensing chromophores are focused by the plurality of lenses to the at least one VPG and transmitted to the detector. The detector being operable to generate spectra with each spectrum corresponding to an individual light signal from a single analyte-sensing chromophore.

Abstract: The present invention relates to highly porous, bioresorbable electrospun sensors for optical detection of tissue oxygenation and processes of making and using same. Multiple sensor compositions are described that are focused on different applications/oxygen ranges. Such sensors alleviate the risk of leaving the sensor implanted in a subject, typically have as good or better oxygen sensing capabilities and comparable performance life span as non-degradable sensors and unlike sensors made from general bioresorbable materials maintain a desired porosity as they degrade. Thus, such sensors may remain integrated in a subject's body while they degrade and maintain the ability to sense oxygen for their performance life span.