Patents by Inventor Jack T. Rogers

Jack T. Rogers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease
    Patent number: 10022357
    Abstract: The present disclosure relates to methods for treating a neurodegenerative disorder by administering an effective amount of an agent that inhibits or reduces translation of amyloid precursor protein. In some embodiments, the neurodegenerative disorder is Alzheimer's disease or Down syndrome. Also disclosed are methods for decreasing amyloid-beta production in a subject's brain. Further disclosed is a method for restoring or maintaining iron homeostasis in a subject's brain.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: July 17, 2018
    Assignees: THE GENERAL HOSPITAL CORPORATION, THE BROAD INSTITUTE, INC.
    Inventors: Jack T Rogers, Xudong Huang, James Spoonamore
  • AMYLOID PRECURSOR PROTEIN MRNA BLOCKERS FOR TREATING DOWN SYDNROME AND ALZHEIMER'S DISEASE
    Publication number: 20160074367
    Abstract: The present disclosure relates to methods for treating a neurodegenerative disorder by administering an effective amount of an agent that inhibits or reduces translation of amyloid precursor protein. In some embodiments, the neurodegenerative disorder is Alzheimer's disease or Down syndrome. Also disclosed are methods for decreasing amyloid-beta production in a subject's brain. Further disclosed is a method for restoring or maintaining iron homeostasis in a subject's brain.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 17, 2016
    Inventors: Jack T. Rogers, Xudong Huang, James Spoonamore