Abstract: Disclosed are aqueous aerosol droplets containing liposome or interacted liposome-drug or medication combination particles in a continuous phase of air or oxygen-enriched air advantageous for the treatment of a wide variety of diseases. The drug or medication is interacted with the liposome membrane so that on its rupture the drug or medication is not lost from the liposome. Different methods of preparation of the aerosol particles containing the liposome and interacted liposome-drug combination particles are described which can be used in small particle aerosol treatment. The majority of the aerosol droplets containing the liposome particles alone or with drugs has a diameter less than 5 microns and has an aerodynamic mass median diameter ranging from about 1 to 3 microns, and the liposome and interacted-liposome drug particles are substantially uniform in size and less than 1 micron in diameter.

Abstract: Disclosed is a small particle aerosol or nebulizer apparatus effective for providing small particles of aerosol containing drug; that is, particles having a maximum diameter of 10 microns but predominantly 1-2 microns, effective for treating the respiratory tract and lungs and providing respiratory retention of most drugs of at least 50 milligrams up to about 100 milligrams per hour. It has features which result in more efficient output of aerosol containing drugs, provides very small aerosol particles which are readily deposited in the lower respiratory tract and lungs, and provides even flow of drug containing aerosol to a patient when exhaling and inhaling.