Patents by Inventor Jack W. Fisher

Jack W. Fisher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral intermediates for the preparation of carbacephems
    Patent number: 5700933
    Abstract: The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: December 23, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Intermediates for the preparation of carbacephems
    Patent number: 5644051
    Abstract: This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Methods and compounds for the preparation of carbacephems
    Patent number: 5521307
    Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: May 28, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Ester cleavage process for use with .beta.-lactams
    Patent number: 5302711
    Abstract: The present invention provides a novel ester cleavage process for use with .beta.-lactams. The process is useful because of mild conditions necessary to complete the reaction, such conditions being especially suitable for .beta.-lactams.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: April 12, 1994
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Kristina Thomas
  • Thiazolinoazetidinones and process therefor
    Patent number: 4271305
    Abstract: Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.
    Type: Grant
    Filed: December 14, 1979
    Date of Patent: June 2, 1981
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Crystalline 3-hydroxycephalosporin solvates
    Patent number: 4237279
    Abstract: 4'-Nitrobenzyl 7-phenoxyacetamide-3-hydroxy-3-cephem-4-carboxylate forms crystalline solvates with acetic acid, propionic acid and methylene chloride. The corresponding 3-hydroxy-3-cephem sulfoxide forms crystalline solvates with acetic acid, propionic acid and methanol. The described solvates allow for facile isolation and purification of 4'-nitrobenzyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate and its 1-oxide.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: December 2, 1980
    Assignee: Eli Lilly and Company
    Inventor: Jack W. Fisher
  • Halogenating reagents
    Patent number: 4230644
    Abstract: Novel halogenating agents are derived from triaryl phosphites and chlorine or bromine. They are useful in converting 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: October 28, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Process for halogenation of .beta.-lactam compounds
    Patent number: 4226986
    Abstract: Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: October 7, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Process for preparation of penicillin and cephalosporin imino halides
    Patent number: 4211702
    Abstract: Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and chlorine or bromine. The imino halide products are intermediates in the preparation of antibiotic compounds.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: July 8, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher