Abstract: A clamp (5) includes first and second gland members (10, 20) having first and second joint portions (11, 21), first and second locking portions (12, 22), and first and second clamping portions (13, 23) disposed between the joint portions and the locking portions. The first and second joint portions are connected for movement of the first and second gland members between an open position and at least one clamping position. The first locking portion is configured to interlock with the second locking portion to secure the first and second gland members in the at least one clamping position. The first and second locking portions further include corresponding first and second user manipulable release portions (15, 25), independently operable for disengagement of the corresponding one of the first and second locking portions from the other of the first and second locking portions to permit movement of the first and second gland members to the open position.

Abstract: An aseptic connector includes a connector body including an inboard mating portion, an outboard terminal connection, and a central flow element disposed in an internal cavity of the connector body, the central flow element defining a central flow passage, a valve seal disposed at an inboard end of the central flow element, and at least one peripheral flow aperture intersecting the central flow passage outboard of the valve seal. An annular valve element is disposed in the internal cavity between the central flow element and an inner surface of the connector body, and is axially biased into sealing engagement with the valve seal and axially movable along the central flow element to a flow position disengaged from the valve seal to permit fluid flow between the central flow passage and the inboard mating portion of the connector body through the at least one peripheral flow aperture.

Abstract: An aseptic coupling system includes a first and second connectors having inboard mating portions, outboard terminal connections, first and second valve seals, and first and second valve elements. When the first and second connectors are joined in a coupled condition, the first and second valve elements are each moved from a shutoff position in sealing engagement with the first and second valve seals to a flow position separated from the first and second valve seals to permit flow therebetween, thereby defining a flow path between the outboard terminal connections. In the coupled condition, non-wetted surfaces of the first valve seal are sealed off from the flow path by sealing engagement with a flow passage defining annular wall of the second connector, and non-wetted surfaces of the second valve seal are sealed off from the flow path by scaling engagement with a flow passage defining annular wall of the first connector.

Abstract: An aseptic coupling system includes a coupler and a connector including a body defining a plug portion and a connector fluid path and an aseptic cap releasably secured to an end of the plug portion. The coupler includes a housing defining a socket portion for receiving the plug portion and a cavity adjacent to the socket portion, a seal translating element assembled with the housing, and an actuator element connected to the seal translating element and operable to move the seal translating element from a cap receiving closed position to a cap displacing open position. When the seal translating element is moved from the closed position to the open position, the cap is disengaged from the connector plug portion and a coupler fluid path, defined by the seal translating element, is moved from an offset portion of the coupler housing cavity into alignment with the connector fluid path.

Abstract: An aseptic coupling system includes a first and second connectors having inboard mating portions, outboard terminal connections, first and second valve seals, and first and second valve elements. When the first and second connectors are joined in a coupled condition, the first and second valve elements are each moved from a shutoff position in sealing engagement with the first and second valve seals to a flow position separated from the first and second valve seals to permit flow therebetween, thereby defining a flow path between the outboard terminal connections. In the coupled condition, non-wetted surfaces of the first valve seal are sealed off from the flow path by sealing engagement with a flow passage defining annular wall of the second connector, and non-wetted surfaces of the second valve seal are sealed off from the flow path by scaling engagement with a flow passage defining annular wall of the first connector.