Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: Techniques to provide contextual content are disclosed. In various embodiments, a set of topics inferred programmatically from a corpus of raw content data is obtained. An input is received. A topic with which the input is associated is determined, based at least in part on the input and the set of topics. A contextual content associated with the topic is provided.

Abstract: A method in a networked system for comparing advertising products includes a processor configured to sampling an impression inventory database to produce a first set of impression samples represented by a first product, and a second set of impression samples represented by a second product. The processor is also configured to determine the percentage of the first set of impression samples that are represented by a second product and also the percentage of the second set of impression samples that are represented by the first product. The processor selects the minimum percentage of the two percentages, where the minimum percentage defines the similarity between the first product and the second product.

Abstract: A method of making a shelter spectacle for existing spectacles through a public network, includes the steps of gathering dimensional information on the existing spectacles worn by a user; sending the dimensional information on the existing spectacles to a fulfillment center through the public network; according to the dimensional information sent by the user, producing a shelter spectacles which fit the existing spectacles worn by the user; and sending the shelter spectacles back to the user.

Abstract: A method in a networked system for comparing advertising products includes a processor configured to sampling an impression inventory database to produce a first set of impression samples represented by a first product, and a second set of impression samples represented by a second product. The processor is also configured to determine the percentage of the first set of impression samples that are represented by a second product and also the percentage of the second set of impression samples that are represented by the first product. The processor selects the minimum percentage of the two percentages, where the minimum percentage defines the similarity between the first product and the second product.