Patents by Inventor Jackie Eun-ah Lim

Jackie Eun-ah Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for production of disulfide bond containing proteins in host cells
    Patent number: 7410788
    Abstract: The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor molecule contained at least one disulfide bond. The methods employ a host cell modified to more efficiently produce properly folded disulfide bond containing proteins. The host cells generally contain a mutation in one or more reductase genes, and can be further genetically modified to increase their growth rate, and are further optionally modified to increase the expression of a catalyst of disulfide bond formation. Host cells, methods for using such to produce proteins of interest, proteins of interest produced by these methods are within the scope of the invention.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: August 12, 2008
    Assignees: President and Fellows of Harvard College, Board of Regents, University of Texas System
    Inventors: Jonathan Beckwith, Fredrik Aslund, Paul H. Bessette, George Georgiou, Daniel Ritz, Jackie Eun-ah Lim
  • Compositions and methods for production of disulfide bond containing proteins in host cells
    Patent number: 6872563
    Abstract: The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor molecule contained at least one disulfide bond. The methods employ a host cell modified to more efficiently produce properly folded disulfide bond containing proteins. The host cells generally contain a mutation in one or more reductase genes, and can be further genetically modified to increase their growth rate, and are further optionally modified to increase the expression of a catalyst of disulfide bond formation. Host cells, methods for using such to produce proteins of interest, proteins of interest produced by these methods are within the scope of the invention.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: March 29, 2005
    Assignees: President and Fellows of Harvard College, Board of Regents, University of Texas System
    Inventors: Jonathan Beckwith, Fredrik Aslund, Paul H. Bessette, George Georgiou, Daniel Ritz, Jackie Eun-ah Lim