Patents by Inventor Jacob A. Kaizerman

Jacob A. Kaizerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzamide derivatives and uses related thereto
    Patent number: 8772296
    Abstract: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: July 8, 2014
    Assignee: Amgen Inc.
    Inventors: Jay P. Powers, Michael Degraffenreid, Lisa Julian, Jacob Kaizerman, Dustin McMinn, Yosup Rew, Daqing Sun, Xuelei Yan, Zhulun Wang, Felix Gonzalez Lopez De Turiso
  • PHOSPHORAMIDATE ALKYLATOR PRODRUGS
    Publication number: 20130303778
    Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
    Type: Application
    Filed: July 12, 2013
    Publication date: November 14, 2013
    Inventors: Mark Matteucci, Jian-Xin Duan, Hailong Jiao, Jacob Kaizerman
  • Phosphoramidate alkylator prodrugs
    Patent number: 8507464
    Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: August 13, 2013
    Assignee: Threshold Pharmaceuticals, Inc.
    Inventors: Mark Matteucci, Jian-Xin Duan, Hailong Jiao, Jacob Kaizerman
  • Pyridopyridazine compounds, compositions and methods of use
    Patent number: 8222251
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 17, 2012
    Assignee: Amgen Inc.
    Inventors: Jacob Kaizerman, Brian Lucas, Dustin McMinn, Robert Zamboni
  • Phthalazine compounds, compositions and methods of use
    Patent number: 8153633
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: April 10, 2012
    Assignee: Amgen Inc.
    Inventors: Richard J. Austin, Jacob Kaizerman, Brian Lucas, Dustin L. McMinn, Jay Powers
  • Phosphoramidate Alkylator Prodrugs
    Publication number: 20110251159
    Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
    Type: Application
    Filed: June 17, 2011
    Publication date: October 13, 2011
    Applicant: Threshold Pharmaceuticals, Inc.
    Inventors: Mark Matteucci, Jian-Xin Duan, Hailong Jiao, Jacob Kaizerman
  • Phosphoramidate alkylator prodrugs
    Patent number: 8003625
    Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 23, 2011
    Assignee: Threshold Pharmaceuticals, Inc.
    Inventors: Mark Matteucci, Jian-Xin Duan, Hailong Jiao, Jacob Kaizerman
  • ANTIPATHOGENIC BENZAMIDE COMPOUNDS
    Publication number: 20110178074
    Abstract: The present invention is related to methods of treating bacterial infections in mammals using antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.
    Type: Application
    Filed: January 25, 2008
    Publication date: July 21, 2011
    Applicant: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. BURLI, Jacob Kaizerman, Peter Jones
  • BENZOTHIOPHENE COMPOUNDS HAVING ANTIINFECTIVE ACTIVITY
    Publication number: 20090247513
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Application
    Filed: December 4, 2007
    Publication date: October 1, 2009
    Applicant: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Pyridopyridazine compounds, compositions and methods of use
    Publication number: 20090099173
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Application
    Filed: September 5, 2008
    Publication date: April 16, 2009
    Applicant: Amgen Inc.
    Inventors: Jacob Kaizerman, Brian Lucas, Dustin McMinn, Robert Zamboni
  • Biaryl compounds having anti-infective activity
    Patent number: 7498349
    Abstract: Aromatic compounds exemplified by exhibit antimicrobial activity.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: March 3, 2009
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Jacob A. Kaizerman, Dustin L. McMinn
  • Halogen-substituted thienyl compounds
    Patent number: 7498405
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: March 3, 2009
    Assignee: GeneSoft Pharmaceuticals, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Burli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Phthalazine compounds, compositions and methods of use
    Publication number: 20090048259
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Application
    Filed: June 23, 2008
    Publication date: February 19, 2009
    Applicant: Amgen Inc.
    Inventors: Richard J. Austin, Jacob Kaizerman, Brian Lucas, Dustin L. McMinn, Jay Powers
  • ANTIPATHOGENIC BENZAMIDE COMPOUNDS
    Publication number: 20080200465
    Abstract: The present invention is related to methods of treating viral and protozoan infections in mammals using antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.
    Type: Application
    Filed: January 25, 2008
    Publication date: August 21, 2008
    Applicant: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. BURLI, Jacob Kaizerman, Peter Jones
  • Antipathogenic benzamide compounds
    Patent number: 7348427
    Abstract: Antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: March 25, 2008
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Roland W. Bürli, Jacob Kaizerman, Peter Jones
  • Benzothiophene compounds having antiinfective activity
    Patent number: 7329765
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: February 12, 2008
    Assignee: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Benzamide derivatives and uses related thereto
    Publication number: 20070299080
    Abstract: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.
    Type: Application
    Filed: May 31, 2007
    Publication date: December 27, 2007
    Inventors: Jay Powers, Michael Degraffenreid, Lisa Julian, Jacob Kaizerman, Dustin McMinn, Yosup Rew, Daqing Sun, Xuelei Yan, Zhulun Wang
  • Halogen-substituted thienyl compounds
    Publication number: 20060287247
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Application
    Filed: June 2, 2006
    Publication date: December 21, 2006
    Applicant: GeneSoft Pharmaceuticals, Inc.
    Inventors: Yigong Ge, Matthew Taylor, Eldon Baird, Roland Burli, Jacob Kaizerman, Amanda Martin, Brie Cadman
  • Halogen-substitued thienyl compounds
    Patent number: 7122626
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: October 17, 2006
    Assignee: GeneSoft Pharmceuticals, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Bürli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Biaryl compounds having anti-infective activity
    Publication number: 20060128747
    Abstract: Aromatic compounds exemplified by exhibit antimicrobial activity.
    Type: Application
    Filed: August 1, 2003
    Publication date: June 15, 2006
    Applicant: GENESOFT PHARMACEUTICALS,INC.
    Inventors: Roland Burli, Eldon Baird, Jacob Kaizerman, Dustin McMinn