Abstract: Oxime ether derivatives of the formula (I): ##STR1## wherein Het is a monocyclic heteroaromatic group containing two hetero atoms at least one of which is nitrogen, or a bicyclic heteroaromatic group containing one or two hetero atoms at least one of which is nitrogen, Ar is a phenyl or a 5- or 6-membered monocyclic heteroaromatic group, and R is an alkyl, alkenyl, alkynyl, cyanoalkyl, carbamidoalkyl or aminoalkyl group, or N-oxides thereof, have anti-ulcer activity in the gastro-intestinal tract of mammals.

Abstract: Pharmaceutical compositions having anti-ulcer activity, containing as an active ingredient a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Het is a heteroaromatic group (substituted or unsubstituted), containing one or more nitrogen atoms as hetero atoms and no more than two rings;X is a hydrogen atom or a cyano, trifluoromethyl or an amido group with the formula--C(A)NR.sup.1 R.sup.2, wherein A is oxygen or sulphur, R.sup.1 is hydrogen or a C.sub.1-4 alkyl group, R.sup.2 is hydrogen or a C.sub.1-4 alkyl group, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a 5- to 6-membered heterocyclic ring in which another hetero atom may be present; andR is C.sub.1-6 alkyl, C.sub.5-6 cycloalkyl, C.sub.5-8 cycloalkylalkyl, C.sub.3-6 alkenyl, C.sub.3-4 alkynyl, phenyl C.sub.1-3 alkyl, the phenyl group being optionally substituted by one or more C.sub.1-6 alkyl, halogen, C.sub.

Abstract: Pharmaceutical compositions having anti-ulcer activity, containing as an active ingredient a compound of the formula (I): ##STR1## wherein Het is a pyridinyl group, Ar is a phenyl or a 5- or 6-membered monocyclic heteroaromatic group, and R is an alkyl, alkenyl, alkynyl, cyanoalkyl, carbamidoalkyl or aminoalkyl group, or an N-oxide thereof.