Abstract: Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with non-Hodgkin lymphoma (NHL). In some embodiments, the methods are for treating subjects with relapsed or refractory NHL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.

Abstract: Provided herein are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting and treating a toxicity. In some embodiments, the toxicity is related to cytokine release syndrome (CRS). The methods generally involve assessing a change in a factor indicative of tumor burden in a subject that is associated with and/or correlate to a risk of developing toxicity. In some aspects, the methods can be used to determine if the subject is at risk or likely at risk for developing a toxicity following administration of the cell therapy. Also provided are methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment of risk of developing a toxicity following administration of the therapy. Also provided herein are reagents and kits for performing the methods.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, automatically tag and group those clustered data structures, and provide results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria, rules, indicators, or scenarios so as to generate scores, reports, alerts, or conclusions that the analyst may quickly and efficiently use to evaluate the groups of data clusters.

Abstract: Systems and techniques for sharing security data are described herein. Security rules and/or attack data may be automatically shared, investigated, enabled, and/or used by entities. A security rule may be enabled on different entities comprising different computing systems to combat similar security threats and/or attacks. Security rules and/or attack data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Methods, devices, systems and computer program products enable monitoring and responding to cyber security attacks. One such system relates to a consortium of monitoring companies and an infrastructure including one or more central monitoring stations or local handling stations for a monitoring company are provided. A central monitoring station of a monitoring company detects a cyberattack that has been launched against a client computer system, and requests a local station to respond to the cyberattack via onsite visits or requests additional resources from other monitoring companies through the consortium system. The central monitoring station also sends to the consortium system updates on a cyberattack that is detected or mitigated by a central monitoring station or local handling station of the monitoring company. The monitoring consortium enables stronger capabilities than any individual monitoring company can offer by the combination and coordination of the efforts and resources of the members.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, automatically tag and group those clustered data structures, and provide results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria, rules, indicators, or scenarios so as to generate scores, reports, alerts, or conclusions that the analyst may quickly and efficiently use to evaluate the groups of data clusters.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, automatically tag and group those clustered data structures, and provide results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria, rules, indicators, or scenarios so as to generate scores, reports, alerts, or conclusions that the analyst may quickly and efficiently use to evaluate the groups of data clusters.

Abstract: Systems and methods are provided for enhanced machine learning refinement and alert generation. An example method includes accessing datasets storing customer information reflecting transactions of customers. Individual risk scores are generated for the customers based on the customer information. Generating the risk score includes providing identified occurrences of scenario definitions and customer information as input to one or more machine learning models, the scenario definitions identifying occurrences of specific information reflected in the datasets, with the machine learning models assign respective risk scores to the customers. An interactive user interface is presented.

Abstract: Systems and techniques for sharing security data are described herein. Security rules and/or attack data may be automatically shared, investigated, enabled, and/or used by entities. A security rule may be enabled on different entities comprising different computing systems to combat similar security threats and/or attacks. Security rules and/or attack data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Discussed herein are embodiments of methods and systems which allow engineers or administrators to create modular plugins which represent the logic for various fault detection tests that can be performed on data pipelines and shared among different software deployments. In some cases, the modular plugins each define a particular test to be executed against data received from the pipeline in addition to one or more configuration points. The configuration points represent configurable arguments, such as variables and/or functions, referenced by the instructions which implement the tests and that can be set according to the specific operation environment of the monitored pipeline.

Abstract: Systems and techniques for sharing security data are described herein. Security rules and/or attack data may be automatically shared, investigated, enabled, and/or used by entities. A security rule may be enabled on different entities comprising different computing systems to combat similar security threats and/or attacks. Security rules and/or attack data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Discussed herein are embodiments of methods and systems which allow engineers or administrators to create modular plugins which represent the logic for various fault detection tests that can be performed on data pipelines and shared among different software deployments. In some cases, the modular plugins each define a particular test to be executed against data received from the pipeline in addition to one or more configuration points. The configuration points represent configurable arguments, such as variables and/or functions, referenced by the instructions which implement the tests and that can be set according to the specific operation environment of the monitored pipeline.

Abstract: Discussed herein are embodiments of methods and systems which allow engineers or administrators to create modular plugins which represent the logic for various fault detection tests that can be performed on data pipelines and shared among different software deployments. In some cases, the modular plugins each define a particular test to be executed against data received from the pipeline in addition to one or more configuration points. The configuration points represent configurable arguments, such as variables and/or functions, referenced by the instructions which implement the tests and that can be set according to the specific operation environment of the monitored pipeline.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, automatically tag and group those clustered data structures, and provide results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria, rules, indicators, or scenarios so as to generate scores, reports, alerts, or conclusions that the analyst may quickly and efficiently use to evaluate the groups of data clusters.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, automatically tag and group those clustered data structures, and provide results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria, rules, indicators, or scenarios so as to generate scores, reports, alerts, or conclusions that the analyst may quickly and efficiently use to evaluate the groups of data clusters.

Abstract: Systems and techniques for sharing security data are described herein. Security rules and/or attack data may be automatically shared, investigated, enabled, and/or used by entities. A security rule may be enabled on different entities comprising different computing systems to combat similar security threats and/or attacks. Security rules and/or attack data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Systems and techniques for sharing security data are described herein. Security rules and/or attack data may be automatically shared, investigated, enabled, and/or used by entities. A security rule may be enabled on different entities comprising different computing systems to combat similar security threats and/or attacks. Security rules and/or attack data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Systems and techniques for sharing healthcare fraud data are described herein. Healthcare fraud detection schemes and/or fraud data may be automatically shared, investigated, enabled, and/or used by entities. A healthcare fraud detection scheme may be enabled on different entities comprising different computing systems to combat similar healthcare fraud threats, instances, and/or attacks. Healthcare fraud detection schemes and/or fraud data may be modified to redact sensitive information and/or configured through access controls for sharing.

Abstract: Discussed herein are embodiments of methods and systems which allow engineers or administrators to create modular plugins which represent the logic for various fault detection tests that can be performed on data pipelines and shared among different software deployments. In some cases, the modular plugins each define a particular test to be executed against data received from the pipeline in addition to one or more configuration points. The configuration points represent configurable arguments, such as variables and/or functions, referenced by the instructions which implement the tests and that can be set according to the specific operation environment of the monitored pipeline.

Abstract: Discussed herein are embodiments of methods and systems which allow engineers or administrators to create modular plugins which represent the logic for various fault detection tests that can be performed on data pipelines and shared among different software deployments. In some cases, the modular plugins each define a particular test to be executed against data received from the pipeline in addition to one or more configuration points. The configuration points represent configurable arguments, such as variables and/or functions, referenced by the instructions which implement the tests and that can be set according to the specific operation environment of the monitored pipeline.