Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A torque barrel for use with a brake system may comprise a torque barrel having a cylindrical structure including an inner surface, an outer surface, a first opening at a first end, and a second opening at an opposing second end; and a longitudinal hole disposed through the outer surface of the barrel between a first spline of the plurality of splines and a second spline of the plurality of splines.

Abstract: Systems and methods for presenting an interface for additional content suggestion can include obtaining data descriptive of the displayed content and determining additional content associated with the displayed content. An interface can then be provided that displays data associated with the displayed content and the additional content. The interface can include a first viewing window for displaying a portion of the displayed content and a second viewing window for displaying a snippet associated with the additional content.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Abstract: A piston assembly is disclosed herein. The piston assembly includes a piston having a first end, an opposing second end, and a sidewall extending from the first end to the second end, the piston further including a cavity at least partially defined by the sidewall, a spring guide having a first end and an opposing second end, the spring guide disposed within the cavity of the piston and adjacent the sidewall, an insulator having a first portion extending from the second end of the piston and a second portion disposed within the piston, an insulator shield disposed adjacent the first portion of the insulator, and a component coupled to the second end of the spring guide, the component being offset from the insulator shield by a distance.

Abstract: Launch and/or recovery for unmanned aircraft and/or other payloads, including via parachute-assist, and associated systems and methods are disclosed. An example system includes a rocket, a carriage, a guide element, and a launch guide. The carriage is coupled to the rocket and is configured to releasably support an unmanned aerial vehicle (UAV). The guide element is coupled to the rocket. The launch guide is configured to be engaged by the guide element during a launch of the rocket while the carriage is supporting the UAV. The guide element is configured to move along the launch guide during the launch.

Abstract: A heat shield for a wheel assembly may comprise a plurality of heat shield segments and a plurality of heat shield retainers coupled to the plurality of heat shield segments. A plurality of shield bumpers may be coupled to a radially outward surface of each heat shield segment of the plurality of arcuate heat shield segments. A first retainer bumper may be located over a first radially outward surface of each heat shield retainer of the plurality of heat shield retainers.

Abstract: A heat shield for an aircraft wheel assembly is made of a heat shield material evenly distributed across the heat shield along both the circumferential and the axial directions. The heat shield material has a high thermal conductivity greater than 30 W/mK. In various embodiments, the thermal conductivity is greater than 85 W/mK. In this manner, thermal flux is maximized throughout the heat shield to distribute heat evenly across the heat shield in both circumferential and axial directions.

Abstract: A torque barrel for use with a brake system may comprise a torque barrel having a cylindrical structure including an inner surface, an outer surface, a first opening at a first end, and a second opening at an opposing second end; and a longitudinal hole disposed through the outer surface of the barrel between a first spline of the plurality of splines and a second spline of the plurality of splines.

Abstract: A wheel and brake assembly comprising: a stator; a rotating assembly mounted around and rotatable relative to the stator about an axis A; a torque tube in fixed engagement with the stator; a stack of brake disks mounted about the torque tube, the stack of brake disks comprising alternate rotor disks and stator disks, the stator disks attached to the torque tube and the rotor disks attached to the rotating assembly; a brake actuator configured to, in response to a brake command, apply a pressing force on the stack of brake disks to cause frictional engagement between the rotor disks and the stator disks such that the stator disks prevent the rotor disks and, hence the rotating assembly, from rotating relative to the torque tube.

Abstract: Methods and apparatus to recover unmanned aerial vehicles (UAVs) with kites are disclosed. A disclosed example apparatus to recover a UAV during flight includes a tether line, a tensioner operatively coupled to the tether line, and a kite operatively coupled to the tether line to support the tether line for recovery of the UAV.

Abstract: A wall cabinet for attachment to a wall includes a carcass that is fixable to a wall and a shelving unit that is housed within the carcass. The shelving unit is movable relative to the carcass between a first position, wherein the shelving unit is housed within the carcass, and second position, wherein the shelving unit extends at least partially beneath the carcass. Sensors may be provided to detect a position of a door of the cabinet, detect an environment beneath the shelving unit, and/or detect an acceleration of the shelving unit. The shelving unit includes a bottom shelf and a further shelf, and the bottom shelf protrudes forward beyond the further shelf.

Abstract: A method of controlling a worktop unit including a frame configured to support a worksurface and a leg configured to support the frame such that the frame is movable relative to the leg between a first position and a second position having a greater elevation than the first position; and a sensor configured to detect an environment beneath the worktop unit and/or a sensor configured to detect an acceleration of the frame, includes the steps of: determining whether a safety condition is satisfied, the safety condition being a condition for avoiding collision between the worktop unit and its environment; or a crush condition; and if the safety condition is satisfied, moving the frame between the first position and the second position.

Abstract: Launch and/or recovery for unmanned aircraft and/or other payloads, including via parachute-assist, and associated systems and methods are disclosed. An example unmanned aerial vehicle (UAV) system includes a lift device, a parachute, and a capture line. The lift device includes a canister. The parachute is stowed in and deployable from the canister. The capture line is attached to the parachute and to a line control device. The capture line is configured to be engaged by a capture device located at an end of a wing of a UAV.

Abstract: Methods and apparatus to deploy unmanned aerial vehicles (UAVs) by kites are disclosed. An example apparatus to deploy a UAV includes a tether line to support the UAV, a tensioner operatively coupled to the tether line, and a kite operatively coupled to the tether line to support the tether line for deployment of the UAV.

Abstract: A heat shield for an aircraft wheel assembly is made of a heat shield material evenly distributed across the heat shield along both the circumferential and the axial directions. The heat shield material has a high thermal conductivity greater than 30 W/mK. In various embodiments, the thermal conductivity is greater than 85 W/mK. In this manner, thermal flux is maximized throughout the heat shield to distribute heat evenly across the heat shield in both circumferential and axial directions.

Abstract: Launch and/or recovery for unmanned aircraft and/or other payloads, including via parachute-assist, and associated systems and methods are disclosed. An example unmanned aerial vehicle (UAV) system includes a lift device, a parachute, and a capture line. The lift device includes a canister. The parachute is stowed in and deployable from the canister. The capture line is attached to the parachute and to a line control device. The capture line is configured to be engaged by a capture device located at an end of a wing of a UAV.

Abstract: Various methods, apparatuses/systems, and media for implementing a payment optimizer application module are disclosed. A supplier system accepts a predefined fixed net payment term for all participating buyers on a network. A processor determines weighted average cost of capital (WACC) data of buyer key data points from buyer audited statements data corresponding to a payment file data and WACC data of supplier key data points from supplier audited statements data corresponding to the payment file data. The processor also determines an optimal disbursement date of payment over the predefined fixed net payment term based on the WACC data; applies the stored set of payment rules to determine an optimal payment method corresponding to the WACC data; and automatically executes disbursement of a payment to the supplier in accordance with the optimal disbursement date based on the optimal payment method.