Abstract: A fish-friendly centrifugal pump having an impeller. The impeller includes a base that is concentric relative to a rotational axis of the impeller and an impeller body formed as at least one oblique cone having an eccentric apex and a smooth outer surface. The at least one oblique cone extends from the base.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A pump comprising an impeller having a hub base and an impeller body. The impeller body comprises a base which is concentric relative to a rotational axis of the impeller, and at least one eccentric apex.

Abstract: Selecting and presenting messages to user of an activity/health monitoring platform. The health/activity monitoring platform may receive physiological data for a user. The health/activity monitoring platform may identify a set of messages based on the physiological data. The health/activity monitoring platform may also determine a set of scores for the set of messages. Each score from the set of scores may be associated with a message from the set of messages and each score from the set of scores may be indicative of whether a respective message should be presented to the user. The health/activity monitoring platform may also identify a first message from a set of messages based on the set of scores and cause the first message to be presented via a display of a computing device of the user. The health/activity monitoring platform may also update a first set of penalties associated with the first message in response to causing the first message to be presented.

Abstract: A pump comprising an impeller having a hub base and an impeller body. The impeller body comprises a base which is concentric relative to a rotational axis of the impeller, and at least one eccentric apex.

Abstract: Selecting and presenting messages to user of an activity/health monitoring platform. The health/activity monitoring platform may receive physiological data for a user. The health/activity monitoring platform may identify a set of messages based on the physiological data. The health/activity monitoring platform may also determine a set of scores for the set of messages. Each score from the set of scores may be associated with a message from the set of messages and each score from the set of scores may be indicative of whether a respective message should be presented to the user. The health/activity monitoring platform may also identify a first message from a set of messages based on the set of scores and cause the first message to be presented via a display of a computing device of the user. The health/activity monitoring platform may also update a first set of penalties associated with the first message in response to causing the first message to be presented.

Abstract: The disclosure describes devices and systems for determining alternative electrode combinations and power consumption for these alternative electrode combinations. In one example, a method includes identifying a set of one or more electrodes configured to deliver electrical stimulation therapy via a lead, determining, based on the set of one or more electrodes, one or more alternative electrode combinations for delivering electrical stimulation therapy, calculating, for each of the one or more alternative electrode combinations, a respective field similarity score with respect to the set of one or more electrodes, and outputting a representation of at least one of the one or more alternative electrode combinations for selection in at least partially defining electrical stimulation therapy, the representation comprising an indication of at least one of the respective power consumption values or the respective field similarity scores.

Abstract: The disclosure describes devices and systems that include a grounding electrode. In one example, a system may include a first module including a pulse generator within a first housing, a second module comprising a switch matrix within a second housing distinct from the first housing, a connecting cable that connects the first module to the second module, a grounding electrode disposed distal of the first module and proximal of the second module, and a plurality of electrodes disposed distal of the second module, wherein each electrode of the plurality of electrodes are selectively coupled to the pulse generator via the switch matrix. These devices or system can be used to provide neurostimulation and/or neurorecording.

Abstract: An electronic module for a system for neural applications comprising a housing and a filtering element that form a closed, miniaturized Faraday cage a corresponding lead, active lead can, a controller and systems.

Abstract: This invention relates to an implantable medical system, where an implantable device including a power source operable connected to electrical components is adapted to generate electrical pulses, and a probe having a distal-end and a proximal-end. The distal-end has one or more electrodes adapted to be in electrical contact with a target tissue and wires for connecting the one or more electrodes to the implantable device. The wires conduct the electrical pulses from the implantable device to the one or more electrodes and into the target tissue. The probe has at least one capacitor and wires for connecting the at least one capacitor to the electrical components in the implantable device such that the at least one capacitor forms a part of the electrical components of the implantable device.

Abstract: The present invention relates to an interface means, especially an interface means for a medical device, comprising at least one or more lines, whereby the lines are configured such that each line has at least one specific functionality and/or is able to connect a first connection means with a second connection means, and at least one grouping and/or redistributing means, wherein the at least one grouping and/or redistributing means is configured such that the lines can be grouped and/or redistributed onto one or more lines and/or the functionality of lines can be grouped and/or redistributed onto one or more lines, preferably onto at least one single line. Furthermore, the present invention relates to a method for communicating a plurality of signals, in particular power and/or data signals and/or control signals, over a plurality of lines.

Abstract: An article of apparel is provided having sleeves with a first panel, a second panel and a third panel. The first panel is generally located on a medial portion of the sleeve, and the second panel and the third panel are generally located on a lateral portion of the sleeve. The sleeves may also comprise an elastically resilient panel positioned adjacent at least the second panel, such that the elastically resilient panel provides increased range of motion for a wearer.

Abstract: Selecting and presenting messages to user of an activity/health monitoring platform. The health/activity monitoring platform may receive physiological data for a user. The health/activity monitoring platform may identify a set of messages based on the physiological data. The health/activity monitoring platform may also determine a set of scores for the set of messages. Each score from the set of scores may be associated with a message from the set of messages and each score from the set of scores may be indicative of whether a respective message should be presented to the user. The health/activity monitoring platform may also identify a first message from a set of messages based on the set of scores and cause the first message to be presented via a display of a computing device of the user. The health/activity monitoring platform may also update a first set of penalties associated with the first message in response to causing the first message to be presented.

Abstract: The present invention relates to an electronic system for a system for neural applications, comprising at least one first connector element and at least one second connector element, the first connector element being configured such that the electronic system is directly and/or indirectly connectable or connected to a controller which is at least configured to supply and/or provide and/or measure at least one voltage and/or at least one current and/or at least one voltage waveform and/or at least one current waveform especially via one or more stimulation outputs and/or recording inputs, the second connector element being configured such that the electronic system is directly and/or indirectly connectable or connected to a lead for neural stimulation and/or recording, wherein the electronic system comprises at least one leakage current detection means configured such that a leakage current, especially a leakage current within and/or around the system for neural applications is detectable.

Abstract: The disclosure describes tissue resistance measurement techniques. To avoid errors caused by bandwidth limitations of the amplifier that amplifies a signal used to determine the tissue resistance, the disclosure describes determining values at different frequencies, where the values include respective error values. The respective error values are proportional to the respective frequencies, and based on this relationship the error value can be removed from the tissue resistance measurement.

Abstract: In one example, a method includes delivering, via one or more stimulation generators of a medical device implanted in a patient, electrical stimulation to the patient. In this example, the method also includes disturbing, by one or more components of the medical device, an image of the patient generated by a magnetic resonance image (MRI) scanner.

Abstract: The disclosure describes devices and systems for determining alternative electrode combinations and power consumption for these alternative electrode combinations. In one example, a method includes identifying a set of one or more electrodes configured to deliver electrical stimulation therapy via a lead, determining, based on the set of one or more electrodes, one or more alternative electrode combinations for delivering electrical stimulation therapy, calculating, for each of the one or more alternative electrode combinations, a respective field similarity score with respect to the set of one or more electrodes, and outputting a representation of at least one of the one or more alternative electrode combinations for selection in at least partially defining electrical stimulation therapy, the representation comprising an indication of at least one of the respective power consumption values or the respective field similarity scores.

Abstract: An article of apparel is provided having sleeves with a first panel, a second panel and a third panel. The first panel is generally located on a medial portion of the sleeve, and the second panel and the third panel are generally located on a lateral portion of the sleeve. The sleeves may also comprise an elastically resilient panel positioned adjacent at least the second panel, such that the elastically resilient panel provides increased range of motion for a wearer.

Abstract: Various examples provide devices, systems, and techniques for dissipating electromagnetic interference (EMI) induced energy in a medical device. In one example, an implantable electronic device includes a housing, at least one connector coupled to the housing and configured to at least one of receive first electrical signals or transmit second electrical signals, and an integrated circuit disposed within the housing, wherein the integrated circuit comprises at least one clamp stage coupled to a supply line of the integrated circuit, and wherein the at least one clamp stage is configured to dissipate magnetic resonance imaging (MRI) induced energy from the supply line in response to at least one of a voltage or a current on the supply line exceeding a respective predetermined voltage threshold value or a current threshold value.

Abstract: The disclosure describes devices and systems for determining alternative electrode combinations and power consumption for these alternative electrode combinations. In one example, a method includes identifying a set of one or more electrodes configured to deliver electrical stimulation therapy via a lead, determining, based on the set of one or more electrodes, one or more alternative electrode combinations for delivering electrical stimulation therapy, calculating, for each of the one or more alternative electrode combinations, a respective field similarity score with respect to the set of one or more electrodes, and outputting a representation of at least one of the one or more alternative electrode combinations for selection in at least partially defining electrical stimulation therapy, the representation comprising an indication of at least one of the respective power consumption values or the respective field similarity scores.