Abstract: The present invention relates to a spray of microjets emanating at an inclined angle from nozzles comprised in a substantially planar membrane layer. A spray nozzle unit for spraying a plurality of fluidic microjets from a pressurized liquid comprises a substantially planar (semiconductor) support having an upstream surface and a downstream surface, and a spray membrane layer arranged on the downstream surface of the support. The spray membrane layer comprises a plurality of nozzle orifices each configured for spraying a fluidic microjet in a Rayleigh regime. Thee support defines a cavity extending from the upstream surface to the spray membrane layer. The cavity is in fluid communication with each one of the nozzle orifices for supplying the pressurized liquid to the nozzle orifices. A position of the nozzle orifices, seen along a direction perpendicular to the downstream surface, is offset in respect of a centre of the cavity.

Abstract: The present invention relates to a spray of microjets emanating at an inclined angle from nozzles comprised in a substantially planar membrane layer. A spray nozzle unit for spraying a plurality of fluidic microjets from a pressurized liquid comprises a substantially planar (semiconductor) support having an upstream surface and a downstream surface, and a spray membrane layer arranged on the downstream surface of the support. The spray membrane layer comprises a plurality of nozzle orifices each configured for spraying a fluidic microjet in a Rayleigh regime. Thee support defines a cavity extending from the upstream surface to the spray membrane layer. The cavity is in fluid communication with each one of the nozzle orifices for supplying the pressurized liquid to the nozzle orifices. A position of the nozzle orifices, seen along a direction perpendicular to the downstream surface, is offset in respect of a centre of the cavity.

Abstract: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a number of openings (preferably precise) which yield minimal detrimental effect both quantitatively and qualitatively on cells present in the bodily fluid during the separation process. For example, in some embodiments, a majority percentage of circulating tumor cells are captured by a filter while a majority percentage of leukocytes, for example, are allowed to pass, where the passed leukocytes retain their vitality.

Abstract: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a number of openings (preferably precise) which yield minimal detrimental effect both quantitatively and qualitatively on cells present in the bodily fluid during the separation process. For example, in some embodiments, a majority percentage of circulating tumor cells are captured by a filter while a majority percentage of leukocytes, for example, are allowed to pass, where the passed leukocytes retain their vitality.