Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A system for space heating or cooling a heated space includes a heat pump including a refrigeration circuit for transferring heat between a heat source and a heat load for heating and cooling operations. A controller controls the heat pump to perform the heating and cooling operations. A user interface receives user inputs, wherein the user inputs include an indication of discomfort based on temperature. The controller creates a profile for a minimum comfortable temperature level and a maximum comfortable temperature level, and the controller controls the heat pump to perform the heating and cooling operations in accordance with the profiles for the minimum and maximum comfortable temperature levels. The controller may generate an optimized heat demand plan in accordance with predictions of outdoor and indoor temperature, cost, and demand. The plan is optimized to cost-effectively maintain the temperature of the heated space within the comfortable temperature range defined by the profiles.

Abstract: A heating system includes a heat pump that provides heat to a major fluid circuit and a minor fluid circuit for performing different heating operations. The system includes a power source having a variable cost and a controller configured to regulate flow of the major and minor fluid circuits to perform the heating operations. The controller is configured to receive information regarding the variable cost of the power source and distribute flow between the major and minor fluid circuits to perform the heating operations to minimize the electricity cost. The combined enhanced demand regulation and enhanced output regulation amplifies the total heat output and power consumption while permitting greater use of a power source of varying cost (e.g. PV)—thereby minimizing overall daily operating cost.

Abstract: A fluid coupler for hydronic solar panels, framed with a rigid frame that, when engaged includes a male coupling rigidly attached to a first manifold pipe. The male coupling has a sealing face perpendicular to a longitudinal axis of the first manifold pipe. The coupler includes a female coupling rigidly attached to a second manifold pipe. The female coupling has a sealing face perpendicular to a longitudinal axis of the second manifold pipe and includes a coupling nut longitudinally constrained along and freely rotatable around the axis of the second manifold pipe.