Abstract: An ambulatory respiratory assist device utilizes a cuirass worn on the chest and/or abdomen and supported by a hip belt so that it does not place a load on the patient's shoulders. The belt also supports a ventilator that includes a pump and its power supply, valving, controls and auxiliary equipment. The device is optionally integrated with auxiliary features such as chest wall vibration, which can be achieved by utilizing cuirass pressure modulation, with shoulder or upper arm supports for simulating the “tripod position”, with positive pressure ventilation apparatus, or with patient monitoring. Shoulder or upper arm supports can extend directly from the belt to the shoulders or upper arms, utilized independently of the cuirass, and optionally integrated with one or more of the above-mentioned auxiliary features.

Abstract: Provided herein are compositions comprising a nanoparticle and a D20 tag. The D20 tag comprises dibenzocyclooctyne (DBCO) covalently attached to a protein. Also provided are diagnostic and therapeutic methods utilizing the nanoparticle composition.

Abstract: Compositions comprising a red blood cell (RBC) having non-toxically coupled thereto a nanoparticle having a low shear modulus or low Young's modulus of less than 10 MPa and containing a drug are provided. In one embodiment, the nanoparticles are optionally coated with protein. In another embodiment, the nanoparticle has no cell-specific targeting moiety or tissue-specific targeting moiety or organ-specific targeting moiety associated therewith. Methods of delivering selected drugs to target organs use these compositions both in vivo and ex vivo treatment of disease and for imaging.

Abstract: An ambulatory respiratory assist device utilizes a cuirass worn on the chest and/or abdomen and supported by a hip belt so that it does not place a load on the patient's shoulders. The belt also supports a ventilator that includes a pump and its power supply, valving, controls and auxiliary equipment. The device is optionally integrated with auxiliary features such as chest wall vibration, which can be achieved by utilizing cuirass pressure modulation, with shoulder or upper arm supports for simulating the “tripod position”, with positive pressure ventilation apparatus, or with patient monitoring. Shoulder or upper arm supports can extend directly from the belt to the shoulders or upper arms, utilized independently of the cuirass, and optionally integrated with one or more of the above-mentioned auxiliary features.

Abstract: Compositions comprising a red blood cell (RBC) having non-toxically coupled thereto a nanoparticle having a low shear modulus or low Young's modulus of less than 10 MPa and containing a drug are provided. In one embodiment, the nanoparticles are optionally coated with protein. In another embodiment, the nanoparticle has no cell-specific targeting moiety or tissue-specific targeting moiety or organ-specific targeting moiety associated therewith. Methods of delivering selected drugs to target organs use these compositions both in vivo and ex vivo treatment of disease and for imaging.

Abstract: An engine compartment arrangement for an agricultural harvester comprises an engine (10), a diesel particulate filter (12) coupled to the engine (10) to receive and filter hot exhaust gases therefrom, a fan (14), a radiator (16) disposed in a cooling airflow path in front of the fan (14) and coupled to the engine (10) to cool said engine (10), a cleaning air duct (18) having a first end (20) disposed immediately behind the fan (14) to receive a portion of the air ejected from the fan (14), and having a second end (22) disposed adjacent to the top of the diesel particulate filter (12) to exhaust a jet of the ejected air at a sufficient speed and in sufficient volume across the top surface (24) of the diesel particular filter (12) to prevent an accumulation of agricultural debris on top of the diesel particulate filter (12).

Abstract: An engine compartment arrangement for an agricultural harvester comprises an engine (10), a diesel particulate filter (12) coupled to the engine (10) to receive and filter hot exhaust gases therefrom, a fan (14), a radiator (16) disposed in a cooling airflow path in front of the fan (14) and coupled to the engine (10) to cool said engine (10), a cleaning air duct (18) having a first end (20) disposed immediately behind the fan (14) to receive a portion of the air ejected from the fan (14), and having a second end (22) disposed adjacent to the top of the diesel particulate filter (12) to exhaust a jet of the ejected air at a sufficient speed and in sufficient volume across the top surface (24) of the diesel particular filter (12) to prevent an accumulation of agricultural debris on top of the diesel particulate fitter 12).