Patents by Inventor Jacob CHA

Jacob CHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20210122747
    Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8. X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: June 5, 2020
    Publication date: April 29, 2021
    Inventors: David John MORGANS, Jr., Randall L. HALCOMB, Gustave BERGNES, Hui LI, Lan JIANG, Jacob CHA, Timothy HOM
  • N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20210024516
    Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.
    Type: Application
    Filed: March 4, 2020
    Publication date: January 28, 2021
    Inventors: Lan JIANG, David John MORGANS, Jr., Gustave BERGNES, Chun CHEN, Hui LI, Patrick ANDRE, Randall HALCOMB, Jacob CHA, Timothy HOM
  • AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20210017171
    Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: June 26, 2020
    Publication date: January 21, 2021
    Inventors: Jacob CHA, Chengguo DONG, Timothy HOM, Lan JIANG, Katerina LEFTHERIS, Hui LI, David John MORGANS, JR., Manuel MUNOZ, Maureen REILLY, Yajun ZHENG
  • DOSAGE FORMS AND REGIMENS FOR AMINO ACID COMPOUNDS
    Publication number: 20200352942
    Abstract: The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: April 8, 2020
    Publication date: November 12, 2020
    Inventors: Jacob CHA, Chengguo DONG, Timothy HOM, Lan JIANG, Katerina LEFTHERIS, Hui LI, David J. MORGANS, JR., Manuel MUNOZ, Maureen REILLY, Yajun ZHENG, Martin DECARIS, Scott TURNER
  • Amino acid compounds and methods of use
    Patent number: 10793564
    Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: October 6, 2020
    Assignee: PLIANT THERAPEUTICS, INC.
    Inventors: Jacob Cha, Chengguo Dong, Timothy Hom, Lan Jiang, Katerina Leftheris, Hui Li, David J. Morgans, Jr., Manuel Munoz, Maureen Reilly, Yajun Zheng
  • Amino acid compounds and methods of use
    Patent number: 10696672
    Abstract: The invention relates to compounds of formula (I): formula (I) or a salt thereof wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 30, 2020
    Assignee: Pliant Therapeutics, Inc.
    Inventors: David John Morgans, Jr., Randall L. Halcomb, Gustave Bergnes, Hui Li, Lan Jiang, Jacob Cha, Timothy Hom
  • AMINO ACID COMPOUNDS WITH UNBRANCHED LINKERS AND METHODS OF USE
    Publication number: 20200123151
    Abstract: The invention relates to compounds of formula (A): or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?V?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: June 27, 2019
    Publication date: April 23, 2020
    Inventors: Katerina LEFTHERIS, Maureen REILLY, Darren FINKELSTEIN, Nicole COOPER, Christopher BAILEY, Jacob CHA
  • AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20200109141
    Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: October 8, 2019
    Publication date: April 9, 2020
    Inventors: Jacob CHA, Manuel MUNOZ, Maureen REILLY, Nicole COOPER, Katerina LEFTHERIS, David J. MORGANS, JR., Timothy HOM, Yajun ZHENG
  • N-acyl amino acid compounds and methods of use
    Patent number: 10604520
    Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 31, 2020
    Assignee: Pliant Therapeutics, Inc.
    Inventors: Lan Jiang, David John Morgans, Jr., Gustave Bergnes, Chun Chen, Hui Li, Patrick Andre, Randall L. Halcomb, Jacob Cha, Timothy Hom
  • AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20190322663
    Abstract: The invention relates to compounds of formula (I): formula (I) or a salt thereof wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: December 20, 2017
    Publication date: October 24, 2019
    Inventors: David John MORGANS, Jr., Randall L. HALCOMB, Gustave BERGNES, Hui LI, Lan JIANG, Jacob CHA, Timothy HOM
  • AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20190276449
    Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Application
    Filed: March 7, 2019
    Publication date: September 12, 2019
    Inventors: Jacob CHA, Chengguo DONG, Timothy HOM, Lan JIANG, Katerina LEFTHERIS, Hui LI, David J. MORGANS, JR., Manuel MUNOZ, Maureen REILLY, Yajun ZHENG
  • N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
    Publication number: 20180093984
    Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.
    Type: Application
    Filed: September 7, 2017
    Publication date: April 5, 2018
    Inventors: Lan JIANG, David John MORGANS, JR., Gustave BERGNES, Chun CHEN, Hui LI, Patrick ANDRE, Randall L. HALCOMB, Jacob CHA, Timothy HOM