Patents by Inventor Jacob Clement

Jacob Clement has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS
    Publication number: 20080090847
    Abstract: The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.
    Type: Application
    Filed: December 5, 2007
    Publication date: April 17, 2008
    Applicant: PLIVA D.D.
    Inventors: Scott Moe, Paul Ala, Emanuele Perola, Carlos Faerman, Jacob Clement, Janid Ali, Paul Will, Salvatore Marchese, Andrew Magee, John Gazzaniga, Christopher Faraday, Manuel Navia, Patrick Connelly
  • Compositions and methods for treating or preventing flaviviridae infections
    Publication number: 20060194835
    Abstract: The present disclosure relates generally to compositions having a glucosidase inhibitor (castanospermine or a derivative thereof, such as celgosivir) in combination with adjunctive therapies of compounds that alter immune function (such as interferon) and compounds that alter viral replication (such as nucleoside analogues like ribavirin), which can be used to treat or prevent infections caused by or associated with a virus of the Flaviviridae family, particularly infections caused by or associated with Hepatitis C virus (HCV).
    Type: Application
    Filed: February 9, 2006
    Publication date: August 31, 2006
    Applicant: Migenix Inc.
    Inventors: Dominique Dugourd, Evelina Rubinchik, Jacob Clement, Hillel Friedland