Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A steerable delivery system is provided for delivering a replacement heart valve to a native heart valve location. The steerable delivery system includes an outer sheath assembly having a capsule along a distal end portion for retaining the replacement heart valve in a compressed configuration. The capsule is constructed to provide both compression resistance and flexibility. The capsule may be formed with an outer polymer layer, a metal middle layer located on a radially inner surface of the outer polymer layer, and an inner liner located on a radially inner surface of the metal middle layer. A fluoroelastomer layer is provided for bonding the inner liner to the metal middle layer. The metal middle layer is preferably a metal hypotube.

Abstract: A system for selecting CRISPR guides for knocking out one or more target genes in a target cell from a multiplicity of candidate guides comprises a memory and a processor. The processor determines whether the candidate guide meets a plurality of thresholds. The thresholds are associated with: a transcript support level; targeting a consensus sequence of a target gene; which exon of the target gene is targeted; targeting of a primary transcript, targeting of a common isoform; a precomputed prediction of editing outcomes; mapping to an expressed sequence; fraction of gene expression attributable to targeted transcripts; a common SNP overlap threshold; which exon of the target gene is targeted; overlap of a selected guide; predicted frameshift percentage; maximum and minimum GC content; off target score; where a coding sequence is targeted. In response to meeting the thresholds, the processor selects the candidate guide as a selected CRISPR guide.

Abstract: The present disclosure provides CRISPC-Cas systems for the creating mutated genes within cells within wells of an addressable well plate.

Abstract: A target system for projectiles comprises a support system, a primary target, and a secondary target. The support system defines a support portion. The primary target comprises a target portion defining a front side and a rear side, a hanging portion, and a clip arranged on a rear side of the target portion. The clip is adapted to engage the secondary target to secure a secondary target relative to the primary target. The hanging portion is adapted to engage the support portion of the support system to support the primary target at a desired location.

Abstract: A mounting system for mounting a plurality of sport devices to a plurality of structures comprising a device attachment system and a structure attachment system. The device attachment system comprises a plurality of distal portions and a plurality of proximal portions. The structure attachment system attaches one of the proximal portions to each of the structures. Each of the distal portions is attached to one of the sport devices. Each of the distal portions is detachably attachable to each of the proximal portions to allow each of the sport devices to be detachably attached to each of the plurality of structures.

Abstract: A mounting system for mounting a plurality of sport devices to a plurality of structures comprising a device attachment system and a structure attachment system. The device attachment system comprises a plurality of distal portions and a plurality of proximal portions. The structure attachment system attaches one of the proximal portions to each of the structures. Each of the distal portions is attached to one of the sport devices. Each of the distal portions is detachably attachable to each of the proximal portions to allow each of the sport devices to be detachably attached to each of the plurality of structures.

Abstract: An electrostatic precipitator having an inner electrode extending along the axis of a tubular outer electrode. The inner electrode includes an elongated support electrode connected to a disc shaped discharge electrode having a transverse dimension larger than the transverse dimension of the support electrode. A high potential applied between the outer electrode and the support and discharge electrodes produces a relatively thin, radially and circumferentially uniform electrostatic field between the discharge electrode and the outer electrode, and a non-corona producing electric field between the support electrode and the outer electrode. A particle entrained gas is directed into the outer electrode at the discharge electrode end. The particles are charged by the thin, intense electrostatic field adjacent the discharge electrode, and are subsequently accelerated toward the outer electrode by the electric field extending between the support electrode and the outer electrode.

Abstract: A gas flow regulator disposed within a gas flow path and having integral baffling means thereon to deflect such a gas flow transversely of the direction of the gas flow in a manner to provide a uniform gas distribution where there is a change in cross-sectional areas of the gas flow path. Furthermore, the regulator of the present invention includes valve means thereon to further regulate the gas flow. The gas flow regulator is particularly applicable to dust collecting assemblies, such as electrostatic precipitators.