Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: In certain embodiments a construct for performing gene editing in a mammalian cell is provided. In certain embodiments the construct comprises a targeting moiety that binds a surface marker on a cell (e.g., surface receptor), where the targeting moiety is attached to a complex comprising a class 2 CRISPR/Cas endonuclease complexed with a corresponding CRISPR/Cas guide RNA that hybridizes to a target sequence within the genomic DNA of the cell.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: The invention relates to a wireless access telecommunications system comprising at least an SA-cell with which a terminal in an active mode is configured to have a data connection and an LA-cell on which the terminal in an idle mode is configured to camp. A method for the terminal to at least obtain LA-cell system information and SA-cell system information includes, when the terminal is in the active mode and an SA-cell radio interface of the terminal is enabled, the terminal receiving at least a part of the SA-cell system information for the terminal from the SA-cell via the SA-cell radio interface. The method further includes enabling an LA-cell radio interface of the terminal during one or more of a plurality of LA time periods and receiving at least a part of the LA-cell system information for the terminal from the LA-cell via the LA-cell radio interface.

Abstract: The invention relates to a wireless access telecommunications system comprising at least an SA-cell with which a terminal in an active mode is configured to have a data connection and an LA-cell on which the terminal in an idle mode is configured to camp. A method for the terminal to at least obtain LA-cell system information and SA-cell system information includes, when the terminal is in the active mode and an SA-cell radio interface of the terminal is enabled, the terminal receiving at least a part of the SA-cell system information for the terminal from the SA-cell via the SA-cell radio interface. The method further includes enabling an LA-cell radio interface of the terminal during one or more of a plurality of LA time periods and receiving at least a part of the LA-cell system information for the terminal from the LA-cell via the LA-cell radio interface.

Abstract: A teat for use with a fluid container comprises a deformable mouthpiece for an infant to suck on during a fluid intake action and an inner core disposed within the mouthpiece. An exterior surface of the inner core is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face of the exterior surface of the inner core so that a fluid duct between the mouthpiece and the inner core is defined which allows the infant to perform a peristaltic fluid intake action. At least one of the interior surface of the mouthpiece and the exterior surface of the inner core has at least one protrusion that is designed to form a fluid barrier between the mouthpiece and the inner core at a position for delimiting the fluid duct at the sides thereof.

Abstract: The present invention provides methods and compositions for detecting genomic sequences of interest in living cells. In particular, the present disclosure provides a split-enzyme system that works with guide RNAs and RNA-guided nucleases to produce detectable luminescent signals exclusively in the presence of targeted genomic sequences.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: The present disclosure provides methods and compositions for enhanced editing of genomic DNA. For example, in some embodiments, a subject method is a method of editing genomic DNA of a eukaryotic cell and the method includes introducing into a eukaryotic cell a composition comprising: (a) a linearized non-homologous DNA composition and (b) a genome targeting composition (which includes a genome editing endonuclease, or a nucleic acid encoding the genome editing endonuclease). In some cases in which the genome editing endonuclease is a CRISPR/Cas endonuclease, the genome targeting composition can also include a corresponding CRISPR/Cas guide RNA.

Abstract: A teat for use with a fluid container comprises a deformable mouthpiece for an infant to suck on during a fluid intake action and an inner core disposed within the mouthpiece. An exterior surface of the inner core is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face of the exterior surface of the inner core so that a fluid duct between the mouthpiece and the inner core is defined which allows the infant to perform a peristaltic fluid intake action. At least one of the interior surface of the mouthpiece and the exterior surface of the inner core has at least one protrusion that is designed to form a fluid barrier between the mouthpiece and the inner core at a position for delimiting the fluid duct at the sides thereof.

Abstract: A teat for use with a fluid container comprises a deformable mouthpiece for an infant to suck on during a fluid intake action and an inner core (20) disposed within the mouthpiece. An exterior surface (21) of the inner core (20) is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face (22) of the exterior surface (21) of the inner core (20) so that a fluid duct between the mouthpiece and the inner core (20) is defined which allows the infant to perform a peristaltic fluid intake action. At least one of the interior surface of the mouthpiece and the exterior surface (21) of the inner core (20) has at least one protrusion (23) that is designed to form a fluid barrier between the mouthpiece and the inner core (20) at a position for delimiting the fluid duct at the sides thereof.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: The invention relates to a wireless access telecommunications system comprising at least an SA-cell with which a terminal in an active mode is configured to have a data connection and an LA-cell on which the terminal in an idle mode is configured to camp. A method for the terminal to at least obtain LA-cell system information and SA-cell system information includes, when the terminal is in the active mode and an SA-cell radio interface of the terminal is enabled, the terminal receiving at least a part of the SA-cell system information for the terminal from the SA-cell via the SA-cell radio interface. The method further includes enabling an LA-cell radio interface of the terminal during one or more of a plurality of LA time periods and receiving at least a part of the LA-cell system information for the terminal from the LA-cell via the LA-cell radio interface.

Abstract: The invention relates to a wireless access telecommunications system comprising at least an SA-cell with which a terminal in an active mode is configured to have a data connection and an LA-cell on which the terminal in an idle mode is configured to camp. A method for the terminal to at least obtain LA-cell system information and SA-cell system information includes, when the terminal is in the active mode and an SA-cell radio interface of the terminal is enabled, the terminal receiving at least a part of the SA-cell system information for the terminal from the SA-cell via the SA-cell radio interface. The method further includes enabling an LA-cell radio interface of the terminal during one or more of a plurality of LA time periods and receiving at least a part of the LA-cell system information for the terminal from the LA-cell via the LA-cell radio interface.

Abstract: A teat for use with a fluid container comprises a deformable mouthpiece for an infant to suck on during a fluid intake action and an inner core (20) disposed within the mouthpiece. An exterior surface (21) of the inner core (20) is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face (22) of the exterior surface (21) of the inner core (20) so that a fluid duct between the mouthpiece and the inner core (20) is defined which allows the infant to perform a peristaltic fluid intake action. At least one of the interior surface of the mouthpiece and the exterior surface (21) of the inner core (20) has at least one protrusion (23) that is designed to form a fluid barrier between the mouthpiece and the inner core (20) at a position for delimiting the fluid duct at the sides thereof.

Abstract: A gas-liquid separation device (30) for an anaerobic purification device for purification of wastewater, the gas-liquid separation device comprising: a gas-liquid riser pipe (32); a separation pipe (34) attached to the gas-liquid riser pipe (32), the separation pipe defining an angle with the direction perpendicular to the gas-liquid riser pipe between ?45 degrees and +45 degrees, the separation pipe (34) configured to receive fluid from the gas-liquid riser pipe (32); at least one pipe gas outlet (35) located, when assembled with an anaerobic purification device, in a surface along the separation pipe (34) facing away from the ground, the at least one pipe gas outlet (35) configured to lead at least a portion of the gas in the separation pipe (34) outside the gas-liquid separation device; a hydraulic cyclone (36) attached to the separation pipe (34), the hydraulic cyclone configured to receive fluid from the separation pipe; at least one cyclone gas outlet (37) located in the upper side of the hydraulic c

Abstract: A partitioning component for a feeding bottle device. The feeding bottle device comprising a teat component defining a teat volume therein and a container component defining a container volume therein. The teat component being attachable to the container component by means of an attachment component. The partitioning component comprises a first passage allowing a passage of fluid from the container volume to the teat volume and a second passage allowing a passage of fluid from the teat volume to the container volume, wherein the second passage is provided in the form of a one-way passage. The invention further relates to a corresponding feeding bottle device and a feeding method. The solutions according to the invention reduce the risk of colic-like symptoms for the infant.

Abstract: A process for aerobic treatment of wastewater is provided, which process comprises: (a) supplying a liquid influent comprising wastewater to a reactor containing granular biomass; (b) subjecting the reaction mixture to aerobic conditions comprising a concentration of dissolved oxygen from 0.1 mg/L to 4.0 mg/L, and a hydraulic retention time from 0.5 to 72 hours; (c) separating the reaction mixture into granular biomass and treated wastewater; and (d) recycling separated granular biomass to the reaction mixture. A bioreactor for the process is also disclosed, comprising a reaction vessel provided with an aeration means, a solids separation device with an inlet in the lower part of the reaction vessel having an outlet line for solids arranged to transport separated solids to a riser driven by airlift action and arranged to transport the solids to the upper part of the reaction chamber.

Abstract: A teat (1) for use with a container for containing a fluid comprises a deformable mouthpiece (13) for an infant to suck on, and an inner core (20) disposed within the mouthpiece (13). The mouthpiece (13) has at least one aperture (12) therein for allowing a fluid to flow out of the teat (1). A fluid duct (30) between the mouthpiece (13) and the inner core (20) is defined at the position of a fluid pocket guiding face (23) of the inner core (20) whereby the infant is allowed to perform a peristaltic fluid intake action. The at least one aperture (12) is arranged in a central front area (15) of the mouthpiece (13), while the mouthpiece (13) and the inner core (20) are designed to leave space between them for a fluid flow path from the fluid pocket guiding face (23) to the at least one aperture (12).

Abstract: An anaerobic purification device for purification of wastewater, the anaerobic purification device comprising: a reactor tank (10) configured to, when in operation, have a sludge blanket formed at the bottom part; a fluid inlet (12) for, in operation, introducing influent into the reactor tank, the fluid inlet located in the lower section of the reactor tank (10); at least one gas-collecting system (13); at least one gas-liquid separation device (30); at least one riser pipe (22) connected to the at least one gas-collecting system (13) and discharging into the gas-liquid separation device (30); a downer pipe (24) connected to the gas-liquid separation device (30) and discharging into the bottom of the reactor tank (10); and a fluid outlet (16) comprising means for, in operation, varying the height of the fluid level (19) in the reactor tank within a predetermined range, the fluid outlet arranged at the upper section of the reactor tank (10); wherein the fluid level control means comprises: a fluid valve