Abstract: A microfluidic diagnostic device with a three-dimensional (3D) flow architecture comprises a polymeric body having first and second opposing surfaces and comprising first flow channels in the first opposing surface, second flow channels in the second opposing surface, and connecting flow passages extending through a thickness of the polymeric body to connect the first flow channels to the second flow channels, thereby defining a continuous 3D flow pathway in the polymeric body. The microfluidic diagnostic device also includes a first cover adhered to the first opposing surface to seal the first flow channels, a second cover adhered to the second opposing surface to seal the second flow channels, and one or more access ports in fluid communication with the continuous 3D flow pathway for introducing liquid reagent(s) and/or a sample into the polymeric body.

Abstract: A microfluidic diagnostic device with a three-dimensional (3D) flow architecture comprises a polymeric body having first and second opposing surfaces and comprising first flow channels in the first opposing surface, second flow channels in the second opposing surface, and connecting flow passages extending through a thickness of the polymeric body to connect the first flow channels to the second flow channels, thereby defining a continuous 3D flow pathway in the polymeric body. The microfluidic diagnostic device also includes a first cover adhered to the first opposing surface to seal the first flow channels, a second cover adhered to the second opposing surface to seal the second flow channels, and one or more access ports in fluid communication with the continuous 3D flow pathway for introducing liquid reagent(s) and/or a sample into the polymeric body.

Abstract: A holder for a curette blade having two opposite sides, two opposite lateral edges and a cutting edge extending between the two edges utilizes two arcuate and opposing blade-clamping surfaces mounted for movement toward and away from one another and associated stop pins for abutting the opposite lateral edges of the blade when the blade is held between the blade-clamping surfaces. The blade-clamping surfaces are adapted to bend the blade into the shape of their arcs when the blade-clamping surfaces are moved from an opened condition to a closed condition so that the cutting edge of the blade is bent to an arcuate condition for a cutting or scraping operation. The holder further includes a member for releasably locking the blade-clamping surfaces in their closed condition about a blade.

Abstract: A tissue specimen container for pathological use consists of a hollow cylindrical body member which comprises a permanent magnet and ferro-magnetic end closures which are magnetically held against the end faces of the body member to complete the container. At least one of the end closures includes a screen portion for admitting treating fluid to the interior of the container.