Patents by Inventor Jacob E. VICK

Jacob E. VICK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Type II fatty acid synthesis enzymes in reverse ?-oxidation
    Patent number: 10450593
    Abstract: This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the ?-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the ?-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their ?-, ?-, and ?-functionalized derivatives from renewable carbon sources can be achieved.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: October 22, 2019
    Assignee: William Marsh Rice University
    Inventors: Ramon Gonzalez, James M. Clomburg, Jacob E. Vick
  • TYPE II FATTY ACID SYNTHESIS ENZYMES IN REVERSE ß-OXIDATION
    Publication number: 20160340699
    Abstract: This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the ?-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the ?-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their ?-, ?-, and ?-functionalized derivatives from renewable carbon sources can be achieved.
    Type: Application
    Filed: January 26, 2015
    Publication date: November 24, 2016
    Inventors: Ramon Gonzalez, James M. CLOMBURG, Jacob E. VICK