Abstract: The invention relates to methods of treating stroke comprising administration of a VLA-4 antagonist to a subject after the onset of the stroke, e.g., ischemic stroke (e.g., acute ischemic stroke) or hemorrhagic stroke (e.g., intracerebral hemorrhage), sub-arachnoid hemorrhage, or traumatic brain injury. Kits and articles of manufacture are also described herein.

Abstract: The invention relates, inter alia, to methods of treating stroke, e.g., ischemic stroke, e.g., acute ischemic stroke, and methods of reducing infarct size and/or other neurological deficits associated with stroke, e.g., ischemic stroke, e.g., acute ischemic stroke, using a VLA-4 antagonist such as natalizumab. It was discovered that VLA-4 antagonists such as natalizumab can effectively reduce the infarct size and other associated neurological deficits of a stroke, e.g., an ischemic stroke; e.g., an acute ischemic stroke, e.g., when administered within a specified time period after the onset of the stroke. Also disclosed herein are articles of manufacture and kits for the treatment of stroke, e.g., ischemic stroke, e.g., acute ischemic stroke.

Abstract: Novel magnetorheological elastomer compositions are provided. The magnetorheological elastomers (MREs) may have aligned or randomly arranged magnetizable particles in a thermoset or thermoplastic matrix. The magnetizable particles may be coated to reduce corrosion and/or improve bonding between the particle and the matrix. The magnetizable particles may be flake-shaped. The MREs may have matrices selected from the group consisting of hydrogenated nitrile rubbers, butyl rubbers, ethylene-propylene copolymers and terpolymers, ethylene-acrylic copolymers, fluorinated elastomers, silphenylene-siloxanes, silarylene-siloxanes, poly(carborane-siloxane-acetylene)s and blends thereof.

Abstract: Novel magnetorheological elastomer compositions are provided. The magnetorheological elastomers (MREs) may have aligned or randomly arranged magnetizable particles in a thermoset or thermoplastic matrix. The magnetizable particles may be coated to reduce corrosion and/or improve bonding between the particle and the matrix. The magnetizable particles may be flake-shaped. The MREs may have matrices selected from the group consisting of hydrogenated nitrile rubbers, butyl rubbers, ethylene-propylene copolymers and terpolymers, ethylene-acrylic copolymers, fluorinated elastomers, silphenylene-siloxanes, silarylene-siloxanes, poly(carborane-siloxane-acetylene)s and blends thereof.