Abstract: Disclosed is a toilet chair (1) comprising a chair back (2) including a head part (3) and a bottom part (4) and a seat (5) comprising a front part (6) and a rear part (8), wherein the seat (5) further comprises a toilet opening (7) through which a user may go to the toilet. The bottom part (4) and the rear part (8) are arranged next to each other and the bottom part (4) is arranged to be displaceable outwards in a direction towards the front of the chair (1) and the rear part (8) is arranged to be displaceable upwards in a direction towards the front of the chair (1). Methods for aiding a person in getting undressed or dressed by means of a toilet chair (1) and use of a toilet chair (1) is also disclosed.

Abstract: Disclosed is a toilet chair (1) comprising a chair back (2) including a head part (3) and a bottom part (4) and a seat (5) comprising a front part (6) and a rear part (8), wherein the seat (5) further comprises a toilet opening (7) through which a user may go to the toilet. The bottom part (4) and the rear part (8) are arranged next to each other and the bottom part (4) is arranged to be displaceable outwards in a direction towards the front of the chair (1) and the rear part (8) is arranged to be displaceable upwards in a direction towards the front of the chair (1). Methods for aiding a person in getting undressed or dressed by means of a toilet chair (1) and use of a toilet chair (1) is also disclosed.

Abstract: Cdc25A has a role in a further signalling pathway for DNA repair which operates in response to DNA damage, in which Chk1 or Chk2 are activated following DNA damage and phosphorylate Cdc25A at one or more serine residues, and more particularly at Ser123 and/or Ser262 and/or Ser292 and/or Ser504. The phosphorylated Cdc25A is then recognized by the F-box protein and is then degraded in a proteasome dependent manner, thereby allowing the cells to undergo cell cycle arrest and repair. Accordingly, by interfering with the phosphorylation and/or degradation of Cdc25A and/or using other strategies to maintain Cdc25A level, this pathway can be used to prevent cells from undergoing repair and thereby increasing the accumulation of DNA damage in the cells, e.g. increasing the fraction of tumor cells which can be killed by DNA damaging therapeutic agents, such as radiation or anti-tumor drugs, or which undergo apoptosis.