Patents by Inventor Jacob Feala

Jacob Feala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to chondrisomes from cultured cells
    Patent number: 11903974
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Methods and compositions relating to chondrisomes from blood products
    Patent number: 11903975
    Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Deep Learning for De Novo Antibody Affinity Maturation (Modification) and Property Improvement
    Publication number: 20230307088
    Abstract: Controlling antibody affinity and expression are key to clinical applications. High affinity antibodies correlate with higher specificity and can be used at lower doses. Presently, antibody maturation is tackled with directed evolution methods. In this case, an initial library of mutated binders is seeded into a process and affinity is improved through multiple rounds of mutation and selection. However, the present disclosure employs a machine learning approach to computationally mature antibody sequences using a process having parallels to directed evolution. These antibody sequences can be manufactured into physical antibodies after their computation and verification. Additionally, the present method has the potential to outperform directed evolution when targeting a specific affinity, and is applicable to general protein-protein interactions.
    Type: Application
    Filed: July 28, 2021
    Publication date: September 28, 2023
    Inventors: Zachary Kohl Costello, Jacob Feala, Andrew Lane Beam
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20220396813
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: January 18, 2022
    Publication date: December 15, 2022
    Inventors: Jacob Feala, Yanfang Fu, Jacob Rosenblum Rubens, Robert James Citorik, Michael Travis Mee, Molly Krisann Gibson
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20220160784
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • METHODS AND COMPOSITIONS RELATING TO CHONDRISOMES FROM BLOOD PRODUCTS
    Publication number: 20200306316
    Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.
    Type: Application
    Filed: November 30, 2016
    Publication date: October 1, 2020
    Inventors: Geoffrey von Maltzahn, John Miles Milwid, Michael Mee, Jacob Rosenblum Rubens, David Chess, Kyle Trudeau, Kiana Mahdaviani, Jacob Feala
  • METHODS AND COMPOSITIONS RELATING TO CHONDRISOMES FROM CULTURED CELLS
    Publication number: 20200306315
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: November 30, 2016
    Publication date: October 1, 2020
    Inventors: Geoffrey von Maltzahn, John Miles Milwid, Michael Mee, Jacob Rosenblum Rubens, David Chess, Kyle Trudeau, Kiana Mahdaviani, Jacob Feala
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20190374582
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: January 18, 2019
    Publication date: December 12, 2019
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20170151287
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 1, 2017
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Mee, Jacob Rosenblum Rubens, David Chess, Kyle Trudeau, Kiana Mahdaviani, Jacob Feala
  • Arrhythmia termination detection based on beat pattern
    Publication number: 20060122650
    Abstract: In general, the invention is directed to an apparatus and method for determining whether an identified atrial tachyarrhythmia episode has terminated. The invention enables determination of whether the tachyarrhythmia episode has terminated based on cardiac beat pattern. In some embodiments of the invention, the determination as to whether the episode has terminated is made irrespective of the rate of atrial depolarizations.
    Type: Application
    Filed: December 3, 2004
    Publication date: June 8, 2006
    Inventors: Eduardo Warman, Jacob Feala