Patents by Inventor Jacob Flyvholm Cramer

Jacob Flyvholm Cramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200397031
    Abstract: A spray-dried composition comprising an enzyme which is a ?-galactosidase having transgalactosylating activity and a maltodextrin and/or sodium chloride.
    Type: Application
    Filed: May 26, 2020
    Publication date: December 24, 2020
    Inventors: MORTEN KROG LARSEN, Jens Damgaard, Bjarne Larsen, Jacob Flyvholm Cramer
  • Patent number: 10842163
    Abstract: A host cell capable of expressing a polypeptide having ?-galactosidase and/or transgalactosylating activity and which host cell is modified to be cellulase, mannanase and pectinase deficient.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: November 24, 2020
    Assignee: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Morten Krog Larsen, Jacob Flyvholm Cramer, Jeremy Labarge, Thomas Eisele, Karina Hansen Kjær
  • Publication number: 20200296980
    Abstract: A method of generating a saccharide, especially lactulose or lactosucrose, in the presence of a transgalactosylase enzyme, is described herein.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 24, 2020
    Inventors: Thomas EISELE, Jacob Flyvholm CRAMER, Morten Krog LARSEN
  • Publication number: 20200263115
    Abstract: The present disclosure provides methods, compositions, apparatuses and kits comprising two or more distant related glucoamylases in mashing having a synergistic effect on the released fermentable DPI sugar. Increased levels of DPI being primarily glucose is of high importance for high attenuation brewing applied for brewing low carb or light beers. In some embodiments, the present disclosure provides methods, apparatuses; compositions and kits for the use of two or more glucoamylases to increase the apparent specific activity in the mashing operation.
    Type: Application
    Filed: September 19, 2018
    Publication date: August 20, 2020
    Inventors: Jacob Flyvholm Cramer, Trove Bladt
  • Patent number: 10683523
    Abstract: The present invention describes a process for in situ generation of stable GOS in different dairy products by the use of a transgalactosylating ?-galactosidase.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 16, 2020
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Morten Krog Larsen, Jacob Flyvholm Cramer, Thomas Eisele
  • Publication number: 20190330577
    Abstract: Methods of using thermostable serine proteases are described herein.
    Type: Application
    Filed: December 18, 2017
    Publication date: October 31, 2019
    Inventors: Jacob Flyvholm Cramer, Marc Anton Bernhard Kolkman, Zhen Ma, Martijn Scheffers, Stepan Shipovskov, Marco Van Brussel-Zwijnen, Shukun Yu
  • Publication number: 20190021352
    Abstract: A host cell capable of expressing a polypeptide having ?-galactosidase and/or transgalactosylating activity and which host cell is modified to be cellulase, mannanase and pectinase deficient.
    Type: Application
    Filed: November 6, 2015
    Publication date: January 24, 2019
    Applicant: DuPont Nutrition Biosciences APS
    Inventors: Morten Krog LARSEN, Jacob Flyvholm CRAMER, Jeremy LABARGE, Thomas EISELE, Karina HANSEN KJÆR
  • Publication number: 20180171323
    Abstract: The present disclosure provides methods, compositions, apparatuses and kits comprising ALDC enzymes having a better stability and/or activity, and, optionally, the yield of ALDC enzymes which can be recovered from microorganisms is improved. In some embodiments, the present disclosure provides methods, apparatuses, compositions and kits for the use of metal ions to increase stability and/or activity, and which further can be used to recover the enzymes from microorganisms in improved yields.
    Type: Application
    Filed: May 18, 2016
    Publication date: June 21, 2018
    Inventors: Jacob Flyvholm Cramer, Lene Bojsen Jensen, Anja Hemmingsen Kellett-Smith, Tove Bladt, Sang-Kyu Lee
  • Publication number: 20180142228
    Abstract: The present disclosure provides methods, compositions, apparatuses and kits comprising ALDC enzymes having a better stability and activity, and which further can be recovered from microorganisms in improved yields.
    Type: Application
    Filed: May 18, 2016
    Publication date: May 24, 2018
    Inventors: Jacob Flyvholm Cramer, Anja Hemmingsen Kellett-Smith, Lene Bojsen Jensen, Bjarne Larsen
  • Publication number: 20170339970
    Abstract: A method of generating a saccharide, especially lactulose or lactosucrose, in the presence of a transgalactosylase enzyme, is described herein.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 30, 2017
    Applicant: DuPont Nutrition Biosciences APS
    Inventors: Morten Krog LARSEN, Jacob Flyvholm CRAMER, Thomas EISELE
  • Publication number: 20170318849
    Abstract: A spray-dried composition comprising an enzyme which is a ?-galactosidase having transgalactosylating activity and a maltodextrin and/or sodium chloride.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 9, 2017
    Applicant: DuPont Nutrition Biosciences APS
    Inventors: Morten Krog LARSEN, Jacob Flyvholm CRAMER, Bjarne LARSEN, Jens DAMGAARD
  • Publication number: 20170306309
    Abstract: The present invention relates to variants having glucoamylase activity with improved properties and to compositions comprising these variants suitable for use for example in the production of a food, beverage (e.g. beer), feed, biochemical, or biofuel. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 26, 2017
    Applicant: DuPont Nutrition Biosciences APS
    Inventors: Jacob Flyvholm CRAMER, Peter Edvard DEGN, Igor NIKOLAEV, Viktor ALEKSEYEV, Casper Willem VROEMEN, Daniel TORRES PAZMINO, Neville Marshall FISH
  • Patent number: 9677058
    Abstract: The present invention relates to polypeptides having glucoamylase activity with improved properties and to compositions comprising these polypeptides suitable for use in the production of a food, beverage (e.g. beer), feed, or biofuel. Also described is an improved and cost-effective process for isolating glucoamylases suitable for large scale protein purification procedures. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: June 13, 2017
    Assignee: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Jacob Flyvholm Cramer, Neville Marshall Fish, Peter Edvard Degn, Igor Nikolaev, Paulien Kruithof, Piet Van Solingen, Sander Van Stigt Thans, Suzy Breneman, Jayarama K. Shetty, Sung Ho Lee
  • Publication number: 20170073717
    Abstract: The present invention describes a process for in situ generation of stable GOS in different dairy products by the use of a transgalactosylating ?-galactosidase.
    Type: Application
    Filed: December 11, 2014
    Publication date: March 16, 2017
    Inventors: Morten Krog LARSEN, Jacob Flyvholm CRAMER, Thomas EISELE
  • Publication number: 20150315558
    Abstract: The present invention relates to variants having glucoamylase activity with improved properties and to compositions comprising these variants suitable for use for example in the production of a food, beverage (e.g. beer), feed, biochemical, or biofuel. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process.
    Type: Application
    Filed: August 21, 2013
    Publication date: November 5, 2015
    Applicant: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Jacob Flyvholm Cramer, Peter Edvard Degn, Igor Nikolaev, Viktor Alekseyev, Casper Willem Vroemen, Daniel Torres Pazmino, Neville Marshall Fish
  • Publication number: 20140356922
    Abstract: The present invention relates to polypeptides having glucoamylase activity with improved properties and to compositions comprising these polypeptides suitable for use in the production of a food, beverage (e.g. beer), feed, or biofuel. Also described is an improved and cost-effective process for isolating glucoamylases suitable for large scale protein purification procedures. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process.
    Type: Application
    Filed: December 20, 2012
    Publication date: December 4, 2014
    Inventors: Jacob Flyvholm Cramer, Neville Marshall Fish, Peter Edvard Degn, Igor Nikolaev, Paulien Kruithof, Piet Van Solingen, Sander Van Stigt Thans, Suzy Breneman, Jayarama K. Shetty, Sung Ho Lee
  • Patent number: 8377701
    Abstract: The present invention provides a Sortilin crystal and methods for growing said crystal. The invention furthermore provide methods for design of specific ligands based on the crystal structure of Sortilin. The present invention also relates to the preparation and use of such ligands for the preparation of a medicament for the treatment of disease, damage or disorders of the central and peripheral nervous systems.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: February 19, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Jens Claus Munck Petersen, Poul Nissen, Peder Søndergaard Madsen, Esben Meldgaard Høgh Quistgaard, Morten Keller Grøftehauge, Søren Skou Thirup, Jacob Flyvholm Cramer, Jacob Lauwring Andersen
  • Publication number: 20110160439
    Abstract: The present invention provides a Sortilin crystal and methods for growing said crystal. The invention furthermore provide methods for design of specific ligands based on the crystal structure of Sortilin. The present invention also relates to the preparation and use of such ligands for the preparation of a medicament for the treatment of disease, damage or disorders of the central and peripheral nervous systems.
    Type: Application
    Filed: April 27, 2009
    Publication date: June 30, 2011
    Applicant: H. LUNDBECK A/S
    Inventors: Jens Claus Munck Petersen, Poul Nissen, Peder Søndergaard Madsen, Esben Meldgaard Høgh Quistgaard, Morten Keller Grøftehauge, Søren Skou Thirup, Jacob Flyvholm Cramer, Jacob Lauwring Andersen