Patents by Inventor Jacob Fraser
Jacob Fraser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190031992Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.Type: ApplicationFiled: July 31, 2018Publication date: January 31, 2019Inventors: S. Jordan Kerns, Norman Wen, Carol Lucchesi, Christopher David Hinojosa, Jacob Fraser, Jefferson Puerta, Geraldine Hamilton, Robert Barrett, Clive Svendsen, Daniel Levner, Stephen R. Targan, Michael Workman, Dhruv Sareen, Uthra Rajamani, Magdalena Kasendra
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Publication number: 20180305651Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.Type: ApplicationFiled: October 19, 2016Publication date: October 25, 2018Inventors: S. Jordan Kerns, Norman Wen, Carolina Lucchesi, Christopher David Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Samuel Sances, Clive Svendsen, Daniel Levner, Dhruv Sareen
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Publication number: 20180298331Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.Type: ApplicationFiled: April 17, 2018Publication date: October 18, 2018Inventors: S. Jordan Kerns, Norman Wen, Carolina Lucchesi, Christopher David Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Samuel Sances, Clive Svendsen, Daniel Levner, Dhruv Sareen
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Publication number: 20180298332Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.Type: ApplicationFiled: April 17, 2018Publication date: October 18, 2018Inventors: S. Jordan Kerns, Norman Wen, Carolina Lucchesi, Christopher David Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Samuel Sances, Clive Svendsen, Daniel Levner, Dhruv Sareen
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Publication number: 20180057788Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.Type: ApplicationFiled: November 15, 2016Publication date: March 1, 2018Inventors: Jordan Kerns, Norman Wen, Carol Lucchesi, Christopher Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Sam Sances, Clive Svendsen, Daniel Levner, Dhruv Sareen
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Publication number: 20180024119Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Daniel Levner, Kyung Jin Jang, Jacob Fraser, Jordan Kerns, Antonio Varone, Dongeun Huh
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Publication number: 20180023050Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Daniel Levner, Kyung Jin Jang, Jacob Fraser, Jordan Kerns, Antonio Varone, Dongeun Huh
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Publication number: 20180024120Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Daniel Levner, Kyung Jin Jang, Jacob Fraser, Jordan Kerns, Antonio Varone, Dongeun Huh
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Publication number: 20180024118Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Daniel Levner, Kyung Jin Jang, Jacob Fraser, Jordan Kerns, Antonio Varone, Dongeun Huh
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Publication number: 20180024116Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Daniel Levner, Kyung Jin Jang, Jacob Fraser, Jordan Kerns, Antonio Varone, Dongeun Huh
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Publication number: 20180017583Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180015455Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180015462Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017585Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017584Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Noeman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017586Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Va der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017582Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20170226478Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).Type: ApplicationFiled: March 14, 2017Publication date: August 10, 2017Inventors: Jordan Kerns, Norman Wen, Geraldine Hamilton, Christopher Hinojosa, Jacob Fraser, Catherine Karalis, Janna Nawroth, Dhruv Sareen, Anjoscha Kaus, Berhan Mandefro, Hyoung Shin Park, Ville Kujala
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Patent number: 9410496Abstract: A control system for an internal combustion engine that utilizes an oxygen sensor signal to control at least one fuel injector while generating a false oxygen sensor signal for input to an engine control unit.Type: GrantFiled: September 11, 2012Date of Patent: August 9, 2016Inventors: William E. Kirkpatrick, Jacob Fraser
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Patent number: 9291530Abstract: An apparatus and method are disclosed for sampling and analyzing the exhaust gas or liquid from an internal combustion engine or other device that generates a flow of exhaust gas or liquid during use. The apparatus includes a connector that is adapted to be secured adjacent to an aperture formed through an outlet conduit of an engine or other device that generates a flow of exhaust gas or liquid therethrough during use. A conduit communicates with the connector and is adapted to receive and pass therethrough at least a portion of the exhaust gas or liquid from the outlet conduit. A sensor chamber communicates with the conduit and is adapted to receive and pass therethrough at least a portion of the exhaust gas or liquid from the conduit. A one-way valve only allows the exhaust gas or liquid in the sensor chamber to exit therefrom. Lastly, a sensor senses at least one characteristic of the exhaust gas or liquid in the sensor chamber and generates a signal that is representative of such characteristic.Type: GrantFiled: June 13, 2013Date of Patent: March 22, 2016Assignee: Techlusion CorporationInventors: Mark E. Dobeck, Jacob Fraser